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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SLC22A3
All Species:
10
Human Site:
S66
Identified Species:
20
UniProt:
O75751
Number Species:
11
Phosphosite Substitution
Charge Score:
0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75751
NP_068812.1
556
61280
S66
L
A
E
R
C
G
W
S
P
E
E
E
W
N
R
Chimpanzee
Pan troglodytes
XP_001152133
556
61220
S66
L
A
E
R
C
G
W
S
P
E
E
E
W
N
R
Rhesus Macaque
Macaca mulatta
XP_001097972
676
74091
S187
L
A
E
R
C
G
W
S
P
E
E
E
W
N
R
Dog
Lupus familis
XP_533467
537
59128
A60
G
P
S
A
A
A
L
A
E
R
C
G
W
S
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9WTW5
551
61034
E61
P
R
A
T
A
L
A
E
R
C
A
W
S
P
E
Rat
Rattus norvegicus
O88446
551
61031
E61
P
R
A
T
A
L
A
E
R
C
A
W
S
P
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515393
362
40716
Chicken
Gallus gallus
XP_419620
540
59928
E61
P
G
A
A
D
L
S
E
K
C
G
W
T
L
E
Frog
Xenopus laevis
Q66J54
558
62434
S58
A
N
D
T
W
Y
Q
S
N
N
T
D
R
M
G
Zebra Danio
Brachydanio rerio
NP_998315
562
62704
C62
V
S
E
I
R
E
R
C
G
W
S
L
Q
D
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VCA2
548
60985
L65
I
Y
E
L
S
P
H
L
W
N
L
S
Y
P
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9U539
585
65444
V66
A
F
N
I
P
F
V
V
G
N
P
P
H
T
C
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
78.4
89.5
N.A.
86.3
86.1
N.A.
54.8
71
32.4
51.2
N.A.
34.3
N.A.
27.5
N.A.
Protein Similarity:
100
99.6
79.5
92.4
N.A.
91.5
92
N.A.
58.9
83
52.3
70.2
N.A.
55.2
N.A.
47.5
N.A.
P-Site Identity:
100
100
100
6.6
N.A.
0
0
N.A.
0
0
6.6
6.6
N.A.
6.6
N.A.
0
N.A.
P-Site Similarity:
100
100
100
20
N.A.
0
0
N.A.
0
0
20
26.6
N.A.
20
N.A.
0
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
25
25
17
25
9
17
9
0
0
17
0
0
0
9
% A
% Cys:
0
0
0
0
25
0
0
9
0
25
9
0
0
0
9
% C
% Asp:
0
0
9
0
9
0
0
0
0
0
0
9
0
9
0
% D
% Glu:
0
0
42
0
0
9
0
25
9
25
25
25
0
0
34
% E
% Phe:
0
9
0
0
0
9
0
0
0
0
0
0
0
0
0
% F
% Gly:
9
9
0
0
0
25
0
0
17
0
9
9
0
0
9
% G
% His:
0
0
0
0
0
0
9
0
0
0
0
0
9
0
0
% H
% Ile:
9
0
0
17
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% K
% Leu:
25
0
0
9
0
25
9
9
0
0
9
9
0
9
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% M
% Asn:
0
9
9
0
0
0
0
0
9
25
0
0
0
25
0
% N
% Pro:
25
9
0
0
9
9
0
0
25
0
9
9
0
25
9
% P
% Gln:
0
0
0
0
0
0
9
0
0
0
0
0
9
0
0
% Q
% Arg:
0
17
0
25
9
0
9
0
17
9
0
0
9
0
25
% R
% Ser:
0
9
9
0
9
0
9
34
0
0
9
9
17
9
0
% S
% Thr:
0
0
0
25
0
0
0
0
0
0
9
0
9
9
0
% T
% Val:
9
0
0
0
0
0
9
9
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
9
0
25
0
9
9
0
25
34
0
0
% W
% Tyr:
0
9
0
0
0
9
0
0
0
0
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _