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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SLC22A3 All Species: 9.7
Human Site: T74 Identified Species: 19.39
UniProt: O75751 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.27
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75751 NP_068812.1 556 61280 T74 P E E E W N R T A P A S R G P
Chimpanzee Pan troglodytes XP_001152133 556 61220 T74 P E E E W N R T A P A S R G P
Rhesus Macaque Macaca mulatta XP_001097972 676 74091 T195 P E E E W N R T A P A S R G P
Dog Lupus familis XP_533467 537 59128 E68 E R C G W S P E E E W N R T A
Cat Felis silvestris
Mouse Mus musculus Q9WTW5 551 61034 E69 R C A W S P E E E W N L T T P
Rat Rattus norvegicus O88446 551 61031 E69 R C A W S P E E E W N L T T P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515393 362 40716
Chicken Gallus gallus XP_419620 540 59928 E69 K C G W T L E E E R N F T V L
Frog Xenopus laevis Q66J54 558 62434 Y66 N N T D R M G Y V R L S A P L
Zebra Danio Brachydanio rerio NP_998315 562 62704 R70 G W S L Q D A R R A T V P L I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VCA2 548 60985 N73 W N L S Y P E N E R C S Y Y D
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9U539 585 65444 H74 G N P P H T C H I P E G K E Y
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 78.4 89.5 N.A. 86.3 86.1 N.A. 54.8 71 32.4 51.2 N.A. 34.3 N.A. 27.5 N.A.
Protein Similarity: 100 99.6 79.5 92.4 N.A. 91.5 92 N.A. 58.9 83 52.3 70.2 N.A. 55.2 N.A. 47.5 N.A.
P-Site Identity: 100 100 100 13.3 N.A. 6.6 6.6 N.A. 0 0 6.6 0 N.A. 6.6 N.A. 6.6 N.A.
P-Site Similarity: 100 100 100 26.6 N.A. 6.6 6.6 N.A. 0 0 13.3 6.6 N.A. 13.3 N.A. 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 17 0 0 0 9 0 25 9 25 0 9 0 9 % A
% Cys: 0 25 9 0 0 0 9 0 0 0 9 0 0 0 0 % C
% Asp: 0 0 0 9 0 9 0 0 0 0 0 0 0 0 9 % D
% Glu: 9 25 25 25 0 0 34 34 42 9 9 0 0 9 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % F
% Gly: 17 0 9 9 0 0 9 0 0 0 0 9 0 25 0 % G
% His: 0 0 0 0 9 0 0 9 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 9 % I
% Lys: 9 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % K
% Leu: 0 0 9 9 0 9 0 0 0 0 9 17 0 9 17 % L
% Met: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % M
% Asn: 9 25 0 0 0 25 0 9 0 0 25 9 0 0 0 % N
% Pro: 25 0 9 9 0 25 9 0 0 34 0 0 9 9 42 % P
% Gln: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 17 9 0 0 9 0 25 9 9 25 0 0 34 0 0 % R
% Ser: 0 0 9 9 17 9 0 0 0 0 0 42 0 0 0 % S
% Thr: 0 0 9 0 9 9 0 25 0 0 9 0 25 25 0 % T
% Val: 0 0 0 0 0 0 0 0 9 0 0 9 0 9 0 % V
% Trp: 9 9 0 25 34 0 0 0 0 17 9 0 0 0 0 % W
% Tyr: 0 0 0 0 9 0 0 9 0 0 0 0 9 9 9 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _