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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SLC22A3
All Species:
17.27
Human Site:
Y318
Identified Species:
34.55
UniProt:
O75751
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75751
NP_068812.1
556
61280
Y318
I
A
K
C
N
G
K
Y
L
S
S
N
Y
S
E
Chimpanzee
Pan troglodytes
XP_001152133
556
61220
Y318
I
A
K
C
N
G
K
Y
L
S
S
N
Y
S
E
Rhesus Macaque
Macaca mulatta
XP_001097972
676
74091
Y439
I
A
K
C
N
G
K
Y
L
S
S
S
Y
S
Q
Dog
Lupus familis
XP_533467
537
59128
Y312
I
A
K
C
N
G
K
Y
L
S
P
N
Y
S
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9WTW5
551
61034
H313
V
A
K
C
N
G
K
H
L
S
S
N
Y
S
E
Rat
Rattus norvegicus
O88446
551
61031
H313
V
A
K
C
N
G
K
H
L
S
S
N
Y
S
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515393
362
40716
M144
I
V
G
I
V
I
Q
M
F
F
T
L
G
I
I
Chicken
Gallus gallus
XP_419620
540
59928
Y312
I
A
K
H
N
G
K
Y
L
S
P
H
Y
S
E
Frog
Xenopus laevis
Q66J54
558
62434
L311
E
E
G
E
K
I
T
L
E
S
M
R
S
D
M
Zebra Danio
Brachydanio rerio
NP_998315
562
62704
L315
A
K
E
N
R
K
T
L
S
K
K
I
E
T
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VCA2
548
60985
D305
E
I
Y
E
Q
L
V
D
E
V
A
E
K
K
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9U539
585
65444
D327
V
D
V
D
E
L
V
D
S
M
K
N
H
Q
N
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
78.4
89.5
N.A.
86.3
86.1
N.A.
54.8
71
32.4
51.2
N.A.
34.3
N.A.
27.5
N.A.
Protein Similarity:
100
99.6
79.5
92.4
N.A.
91.5
92
N.A.
58.9
83
52.3
70.2
N.A.
55.2
N.A.
47.5
N.A.
P-Site Identity:
100
100
86.6
93.3
N.A.
86.6
86.6
N.A.
6.6
80
6.6
0
N.A.
0
N.A.
6.6
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
20
86.6
6.6
13.3
N.A.
13.3
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
59
0
0
0
0
0
0
0
0
9
0
0
0
0
% A
% Cys:
0
0
0
50
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
0
9
0
0
0
17
0
0
0
0
0
9
0
% D
% Glu:
17
9
9
17
9
0
0
0
17
0
0
9
9
0
50
% E
% Phe:
0
0
0
0
0
0
0
0
9
9
0
0
0
0
0
% F
% Gly:
0
0
17
0
0
59
0
0
0
0
0
0
9
0
0
% G
% His:
0
0
0
9
0
0
0
17
0
0
0
9
9
0
0
% H
% Ile:
50
9
0
9
0
17
0
0
0
0
0
9
0
9
9
% I
% Lys:
0
9
59
0
9
9
59
0
0
9
17
0
9
9
9
% K
% Leu:
0
0
0
0
0
17
0
17
59
0
0
9
0
0
9
% L
% Met:
0
0
0
0
0
0
0
9
0
9
9
0
0
0
9
% M
% Asn:
0
0
0
9
59
0
0
0
0
0
0
50
0
0
9
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
17
0
0
0
0
% P
% Gln:
0
0
0
0
9
0
9
0
0
0
0
0
0
9
9
% Q
% Arg:
0
0
0
0
9
0
0
0
0
0
0
9
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
17
67
42
9
9
59
0
% S
% Thr:
0
0
0
0
0
0
17
0
0
0
9
0
0
9
0
% T
% Val:
25
9
9
0
9
0
17
0
0
9
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
9
0
0
0
0
42
0
0
0
0
59
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _