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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3G
All Species:
22.73
Human Site:
T66
Identified Species:
45.45
UniProt:
O75821
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75821
NP_003746.2
320
35611
T66
V
I
N
G
N
I
K
T
V
T
E
Y
K
I
D
Chimpanzee
Pan troglodytes
XP_001162623
321
35664
T66
V
I
N
G
N
I
K
T
V
T
E
Y
K
I
D
Rhesus Macaque
Macaca mulatta
XP_001104633
412
45884
T158
V
I
N
G
N
I
K
T
V
T
E
Y
K
I
D
Dog
Lupus familis
XP_854113
320
35548
T66
V
I
N
G
N
I
K
T
V
T
E
Y
K
I
D
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z1D1
320
35620
T66
V
I
N
G
N
I
K
T
V
T
E
Y
K
I
E
Rat
Rattus norvegicus
Q5RK09
320
35633
T66
V
I
N
G
N
I
K
T
V
T
E
Y
K
V
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511404
168
18662
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6DJI8
308
34347
K58
I
K
T
I
T
E
Y
K
L
N
D
D
D
K
T
Zebra Danio
Brachydanio rerio
Q6DRC4
293
32825
G49
E
Y
K
I
D
D
D
G
Q
K
F
K
I
I
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VDM6
273
30508
G29
P
S
N
E
Y
I
K
G
D
F
K
Y
V
T
E
Honey Bee
Apis mellifera
XP_391934
285
31815
N41
I
L
T
E
Y
K
Y
N
Q
D
N
K
K
V
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_791582
297
32824
Q52
E
D
N
N
K
L
I
Q
I
T
R
T
F
K
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
77.6
99.3
N.A.
98.4
98.4
N.A.
46.2
N.A.
83.1
82.1
N.A.
41.8
48.1
N.A.
56.8
Protein Similarity:
100
99.6
77.6
99.6
N.A.
99
99
N.A.
49.3
N.A.
88.4
85.9
N.A.
57.1
61.5
N.A.
68.4
P-Site Identity:
100
100
100
100
N.A.
93.3
86.6
N.A.
0
N.A.
0
6.6
N.A.
26.6
6.6
N.A.
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
0
N.A.
20
13.3
N.A.
40
26.6
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
0
0
9
9
9
0
9
9
9
9
9
0
34
% D
% Glu:
17
0
0
17
0
9
0
0
0
0
50
0
0
0
25
% E
% Phe:
0
0
0
0
0
0
0
0
0
9
9
0
9
0
0
% F
% Gly:
0
0
0
50
0
0
0
17
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
17
50
0
17
0
59
9
0
9
0
0
0
9
50
9
% I
% Lys:
0
9
9
0
9
9
59
9
0
9
9
17
59
17
9
% K
% Leu:
0
9
0
0
0
9
0
0
9
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
67
9
50
0
0
9
0
9
9
0
0
0
0
% N
% Pro:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
9
17
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
9
% R
% Ser:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
17
0
9
0
0
50
0
59
0
9
0
9
9
% T
% Val:
50
0
0
0
0
0
0
0
50
0
0
0
9
17
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
9
0
0
17
0
17
0
0
0
0
59
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _