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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CIB2 All Species: 25.45
Human Site: Y46 Identified Species: 37.33
UniProt: O75838 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75838 NP_006374.1 187 21644 Y46 P N L V P M D Y R K S P I V H
Chimpanzee Pan troglodytes XP_001148235 192 21656 Q46 G H S S R V T Q A V H S L A P
Rhesus Macaque Macaca mulatta XP_001112625 187 21884 Y46 P Q L V P L D Y T T C P D V K
Dog Lupus familis XP_548660 187 21696 Y46 P N L V P M D Y R K S P I V H
Cat Felis silvestris
Mouse Mus musculus Q9Z309 187 21685 Y46 P N L V P M D Y R K S P I V H
Rat Rattus norvegicus Q568Z7 187 21653 Y46 P N L V P M D Y R K S P I V H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510397 225 26316 Y84 P Q L V P L D Y T D Q P E V K
Chicken Gallus gallus XP_413749 187 21661 Y46 P N V V P M D Y T K D P D V K
Frog Xenopus laevis Q3KQ77 208 24147 D49 P N T R R G I D R N T F R N I
Zebra Danio Brachydanio rerio NP_957000 187 21740 Y46 P H L V P M D Y T N D P D V K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24214 170 19248 L46 S V D E F M S L P E L Q Q N P
Honey Bee Apis mellifera XP_623978 200 23103 S46 N P G T V P R S M T P Q Q A S
Nematode Worm Caenorhab. elegans NP_492514 311 35942 M168 P H K V P T N M Q G N R P A I
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O81223 222 25675 L55 S S I I D D G L I H K E E F Q
Baker's Yeast Sacchar. cerevisiae P25296 175 19620 P56 I P G V S S N P L A G R I M E
Red Bread Mold Neurospora crassa P87072 174 19751 P56 L P Q I S T N P L A T R M I A
Conservation
Percent
Protein Identity: 100 80.7 62 97.8 N.A. 97.3 98.4 N.A. 51.5 78.6 23 75.9 N.A. 26.2 45.5 30.8 N.A.
Protein Similarity: 100 83.3 79.1 98.9 N.A. 99.4 99.4 N.A. 63.1 89.3 41.3 87.1 N.A. 45.9 66.5 43.7 N.A.
P-Site Identity: 100 0 53.3 100 N.A. 100 100 N.A. 53.3 66.6 20 60 N.A. 6.6 0 20 N.A.
P-Site Similarity: 100 20 60 100 N.A. 100 100 N.A. 60 73.3 26.6 66.6 N.A. 13.3 0 46.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 25.2 29.4 30.4
Protein Similarity: N.A. N.A. N.A. 37.8 48.6 49.7
P-Site Identity: N.A. N.A. N.A. 0 13.3 0
P-Site Similarity: N.A. N.A. N.A. 20 26.6 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 7 13 0 0 0 19 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % C
% Asp: 0 0 7 0 7 7 50 7 0 7 13 0 19 0 0 % D
% Glu: 0 0 0 7 0 0 0 0 0 7 0 7 13 0 7 % E
% Phe: 0 0 0 0 7 0 0 0 0 0 0 7 0 7 0 % F
% Gly: 7 0 13 0 0 7 7 0 0 7 7 0 0 0 0 % G
% His: 0 19 0 0 0 0 0 0 0 7 7 0 0 0 25 % H
% Ile: 7 0 7 13 0 0 7 0 7 0 0 0 32 7 13 % I
% Lys: 0 0 7 0 0 0 0 0 0 32 7 0 0 0 25 % K
% Leu: 7 0 44 0 0 13 0 13 13 0 7 0 7 0 0 % L
% Met: 0 0 0 0 0 44 0 7 7 0 0 0 7 7 0 % M
% Asn: 7 38 0 0 0 0 19 0 0 13 7 0 0 13 0 % N
% Pro: 63 19 0 0 57 7 0 13 7 0 7 50 7 0 13 % P
% Gln: 0 13 7 0 0 0 0 7 7 0 7 13 13 0 7 % Q
% Arg: 0 0 0 7 13 0 7 0 32 0 0 19 7 0 0 % R
% Ser: 13 7 7 7 13 7 7 7 0 0 25 7 0 0 7 % S
% Thr: 0 0 7 7 0 13 7 0 25 13 13 0 0 0 0 % T
% Val: 0 7 7 63 7 7 0 0 0 7 0 0 0 50 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 50 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _