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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AP1G2 All Species: 30.91
Human Site: S519 Identified Species: 56.67
UniProt: O75843 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75843 NP_003908.1 785 87117 S519 K V L Q S H M S L P A T R G Y
Chimpanzee Pan troglodytes XP_001163717 785 87058 S519 K V L Q S H M S L P A T R G Y
Rhesus Macaque Macaca mulatta XP_001109007 785 86931 S519 K V L Q S H M S L P A T R G Y
Dog Lupus familis XP_537377 787 87286 S519 K V L Q S H M S L P A T R G Y
Cat Felis silvestris
Mouse Mus musculus O88512 791 87846 S519 K V L Q S H M S L P A T R G Y
Rat Rattus norvegicus P18484 938 104026 L525 P L I Q F N L L H S K F H L C
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509435 822 91369 S518 S V L I S N M S T S V T R G Y
Chicken Gallus gallus NP_001006132 821 91444 S521 S V L I S N M S A S V T R G Y
Frog Xenopus laevis NP_001083997 812 90423 S518 S I L I S N M S A S V T R G F
Zebra Danio Brachydanio rerio NP_955976 819 90933 L517 E G L L V S N L S A P V T R G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91926 940 105602 T537 Y H L C S P M T R A L L L S T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_792773 959 106235 S629 S M I Q T T T S S Q I T K E Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q12028 832 93606 L562 E L Y T A T N L K I I N Y I L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97 90.3 N.A. 86.4 24 N.A. 60.4 59.9 59.3 60.3 N.A. 24 N.A. N.A. 42
Protein Similarity: 100 99.8 97.8 94.2 N.A. 91.7 44.5 N.A. 75.5 75.4 76.4 75.5 N.A. 44.2 N.A. N.A. 58.8
P-Site Identity: 100 100 100 100 N.A. 100 6.6 N.A. 60 60 46.6 6.6 N.A. 20 N.A. N.A. 26.6
P-Site Similarity: 100 100 100 100 N.A. 100 33.3 N.A. 66.6 66.6 66.6 13.3 N.A. 26.6 N.A. N.A. 53.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 30.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 49.7 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 8 0 0 0 16 16 39 0 0 0 0 % A
% Cys: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 8 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 16 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % E
% Phe: 0 0 0 0 8 0 0 0 0 0 0 8 0 0 8 % F
% Gly: 0 8 0 0 0 0 0 0 0 0 0 0 0 62 8 % G
% His: 0 8 0 0 0 39 0 0 8 0 0 0 8 0 0 % H
% Ile: 0 8 16 24 0 0 0 0 0 8 16 0 0 8 0 % I
% Lys: 39 0 0 0 0 0 0 0 8 0 8 0 8 0 0 % K
% Leu: 0 16 77 8 0 0 8 24 39 0 8 8 8 8 8 % L
% Met: 0 8 0 0 0 0 70 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 31 16 0 0 0 0 8 0 0 0 % N
% Pro: 8 0 0 0 0 8 0 0 0 39 8 0 0 0 0 % P
% Gln: 0 0 0 54 0 0 0 0 0 8 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 8 0 0 0 62 8 0 % R
% Ser: 31 0 0 0 70 8 0 70 16 31 0 0 0 8 0 % S
% Thr: 0 0 0 8 8 16 8 8 8 0 0 70 8 0 8 % T
% Val: 0 54 0 0 8 0 0 0 0 0 24 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 8 0 0 0 0 0 0 0 0 0 8 0 62 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _