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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AP1G2 All Species: 20.61
Human Site: S646 Identified Species: 37.78
UniProt: O75843 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75843 NP_003908.1 785 87117 S646 H P P H L D P S P G G A L V H
Chimpanzee Pan troglodytes XP_001163717 785 87058 S646 H P P P L D P S P G G A L I H
Rhesus Macaque Macaca mulatta XP_001109007 785 86931 S646 H P P P L D P S P G G A L V Y
Dog Lupus familis XP_537377 787 87286 S644 P P P P L E P S P G D V L V H
Cat Felis silvestris
Mouse Mus musculus O88512 791 87846 P647 S G H A Q H L P P Q T P S P G
Rat Rattus norvegicus P18484 938 104026 S677 A P T G P P P S S G G G L L V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509435 822 91369 S647 V I P T A P T S K P A S A G G
Chicken Gallus gallus NP_001006132 821 91444 S654 A P T S K P A S A G G E L L D
Frog Xenopus laevis NP_001083997 812 90423 S647 V I P T A L P S K P A S V G G
Zebra Danio Brachydanio rerio NP_955976 819 90933 T671 L T G G P A P T P A P S V P M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91926 940 105602 S681 N I G S G S N S N S T L I D V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_792773 959 106235 L823 P G S V P P A L G M N S L L G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q12028 832 93606 K702 Q V P K N A N K E E S I N H S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97 90.3 N.A. 86.4 24 N.A. 60.4 59.9 59.3 60.3 N.A. 24 N.A. N.A. 42
Protein Similarity: 100 99.8 97.8 94.2 N.A. 91.7 44.5 N.A. 75.5 75.4 76.4 75.5 N.A. 44.2 N.A. N.A. 58.8
P-Site Identity: 100 86.6 86.6 66.6 N.A. 6.6 40 N.A. 13.3 33.3 20 13.3 N.A. 6.6 N.A. N.A. 6.6
P-Site Similarity: 100 93.3 93.3 73.3 N.A. 6.6 46.6 N.A. 20 40 33.3 33.3 N.A. 20 N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 30.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 49.7 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 0 0 8 16 16 16 0 8 8 16 24 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 24 0 0 0 0 8 0 0 8 8 % D
% Glu: 0 0 0 0 0 8 0 0 8 8 0 8 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 16 16 16 8 0 0 0 8 47 39 8 0 16 31 % G
% His: 24 0 8 8 0 8 0 0 0 0 0 0 0 8 24 % H
% Ile: 0 24 0 0 0 0 0 0 0 0 0 8 8 8 0 % I
% Lys: 0 0 0 8 8 0 0 8 16 0 0 0 0 0 0 % K
% Leu: 8 0 0 0 31 8 8 8 0 0 0 8 54 24 0 % L
% Met: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 8 % M
% Asn: 8 0 0 0 8 0 16 0 8 0 8 0 8 0 0 % N
% Pro: 16 47 54 24 24 31 54 8 47 16 8 8 0 16 0 % P
% Gln: 8 0 0 0 8 0 0 0 0 8 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 8 0 8 16 0 8 0 70 8 8 8 31 8 0 8 % S
% Thr: 0 8 16 16 0 0 8 8 0 0 16 0 0 0 0 % T
% Val: 16 8 0 8 0 0 0 0 0 0 0 8 16 24 16 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _