Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ZMPSTE24 All Species: 33.33
Human Site: T345 Identified Species: 48.89
UniProt: O75844 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75844 NP_005848.2 475 54813 T345 G H W K L G H T V K N I I I S
Chimpanzee Pan troglodytes XP_513352 475 54806 T345 G H W K L G H T V K N I I I S
Rhesus Macaque Macaca mulatta XP_001082852 475 54874 T345 G H W K L G H T V K N I I I S
Dog Lupus familis XP_539577 422 48642 F307 Q M N S F L C F F L F A V L I
Cat Felis silvestris
Mouse Mus musculus Q80W54 475 54716 T345 G H W K L G H T V K N I I I S
Rat Rattus norvegicus NP_001101444 475 54829 T345 G H W K L G H T V K N I I I S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_417720 465 53514 T335 G H W K L G H T V K N I I I S
Frog Xenopus laevis NP_001087923 465 53504 T335 G H W K L G H T V K N I V I S
Zebra Danio Brachydanio rerio NP_956186 468 53723 T338 G H W K L G H T V K N I V I S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_611175 451 51621 Q324 T K N I I I M Q V H L F L M F
Honey Bee Apis mellifera XP_623864 433 51054 F318 H S H A L K G F I F G Q Y A K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001177479 411 47353 L296 I S Q V N I L L C L F L F A L
Poplar Tree Populus trichocarpa XP_002320821 424 48433 F309 Q I L T F L Q F G G Y T L V R
Maize Zea mays NP_001131195 425 48732 G310 L L M F L Q F G G Y T L V R S
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8RX88 424 48464 F309 Q I L A F L Q F G G Y T L V R
Baker's Yeast Sacchar. cerevisiae P47154 453 52306 S323 L H T F L I F S L F T S I Y R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 99.1 85.4 N.A. 93.4 93.6 N.A. N.A. 86.9 80.4 79.1 N.A. 48 41.8 N.A. 63.3
Protein Similarity: 100 99.7 99.5 87.1 N.A. 96 96.4 N.A. N.A. 92.2 87.3 87.7 N.A. 67.3 61 N.A. 72.8
P-Site Identity: 100 100 100 0 N.A. 100 100 N.A. N.A. 100 93.3 93.3 N.A. 6.6 6.6 N.A. 0
P-Site Similarity: 100 100 100 13.3 N.A. 100 100 N.A. N.A. 100 100 100 N.A. 26.6 13.3 N.A. 6.6
Percent
Protein Identity: 43.3 44.6 N.A. 43.5 34.7 N.A.
Protein Similarity: 59.7 61 N.A. 60.6 52.6 N.A.
P-Site Identity: 0 13.3 N.A. 0 20 N.A.
P-Site Similarity: 13.3 26.6 N.A. 13.3 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 13 0 0 0 0 0 0 0 7 0 13 0 % A
% Cys: 0 0 0 0 0 0 7 0 7 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 13 19 0 13 25 7 13 13 7 7 0 7 % F
% Gly: 50 0 0 0 0 50 7 7 19 13 7 0 0 0 0 % G
% His: 7 57 7 0 0 0 50 0 0 7 0 0 0 0 0 % H
% Ile: 7 13 0 7 7 19 0 0 7 0 0 50 44 50 7 % I
% Lys: 0 7 0 50 0 7 0 0 0 50 0 0 0 0 7 % K
% Leu: 13 7 13 0 69 19 7 7 7 13 7 13 19 7 7 % L
% Met: 0 7 7 0 0 0 7 0 0 0 0 0 0 7 0 % M
% Asn: 0 0 13 0 7 0 0 0 0 0 50 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 19 0 7 0 0 7 13 7 0 0 0 7 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 19 % R
% Ser: 0 13 0 7 0 0 0 7 0 0 0 7 0 0 57 % S
% Thr: 7 0 7 7 0 0 0 50 0 0 13 13 0 0 0 % T
% Val: 0 0 0 7 0 0 0 0 57 0 0 0 25 13 0 % V
% Trp: 0 0 50 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 7 13 0 7 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _