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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ZMPSTE24 All Species: 43.03
Human Site: Y269 Identified Species: 63.11
UniProt: O75844 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75844 NP_005848.2 475 54813 Y269 S H S N A Y F Y G F F K N K R
Chimpanzee Pan troglodytes XP_513352 475 54806 Y269 S H S N A Y F Y G F F K N K R
Rhesus Macaque Macaca mulatta XP_001082852 475 54874 Y269 S H S N A Y F Y G F F K N K R
Dog Lupus familis XP_539577 422 48642 K251 E S G M E P R K D G E G D S E
Cat Felis silvestris
Mouse Mus musculus Q80W54 475 54716 Y269 S H S N A Y F Y G F F K N K R
Rat Rattus norvegicus NP_001101444 475 54829 Y269 S H S N A Y F Y G F F K N K R
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_417720 465 53514 Y267 S H S N A Y F Y G F F K N K R
Frog Xenopus laevis NP_001087923 465 53504 Y264 S H S N A Y F Y G F F K N K R
Zebra Danio Brachydanio rerio NP_956186 468 53723 Y264 S H S N A Y F Y G F F K N K R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_611175 451 51621 G261 H S N A Y F Y G L W N S K R I
Honey Bee Apis mellifera XP_623864 433 51054 Y262 S H S N A Y L Y G F Y K H K R
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001177479 411 47353 D240 N K R I V L F D T L L E D Y K
Poplar Tree Populus trichocarpa XP_002320821 424 48433 M253 S S H S N A Y M Y G F F K N K
Maize Zea mays NP_001131195 425 48732 Y254 S H S N A Y M Y G F F K N K R
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8RX88 424 48464 M253 S S H S N A Y M Y G F F K N K
Baker's Yeast Sacchar. cerevisiae P47154 453 52306 T267 S H S N A Y F T G L P F T S K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 99.1 85.4 N.A. 93.4 93.6 N.A. N.A. 86.9 80.4 79.1 N.A. 48 41.8 N.A. 63.3
Protein Similarity: 100 99.7 99.5 87.1 N.A. 96 96.4 N.A. N.A. 92.2 87.3 87.7 N.A. 67.3 61 N.A. 72.8
P-Site Identity: 100 100 100 0 N.A. 100 100 N.A. N.A. 100 100 100 N.A. 0 80 N.A. 6.6
P-Site Similarity: 100 100 100 6.6 N.A. 100 100 N.A. N.A. 100 100 100 N.A. 33.3 93.3 N.A. 33.3
Percent
Protein Identity: 43.3 44.6 N.A. 43.5 34.7 N.A.
Protein Similarity: 59.7 61 N.A. 60.6 52.6 N.A.
P-Site Identity: 13.3 93.3 N.A. 13.3 53.3 N.A.
P-Site Similarity: 33.3 93.3 N.A. 33.3 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 7 69 13 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 7 7 0 0 0 13 0 0 % D
% Glu: 7 0 0 0 7 0 0 0 0 0 7 7 0 0 7 % E
% Phe: 0 0 0 0 0 7 63 0 0 63 69 19 0 0 0 % F
% Gly: 0 0 7 0 0 0 0 7 69 19 0 7 0 0 0 % G
% His: 7 69 13 0 0 0 0 0 0 0 0 0 7 0 0 % H
% Ile: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 7 % I
% Lys: 0 7 0 0 0 0 0 7 0 0 0 63 19 63 25 % K
% Leu: 0 0 0 0 0 7 7 0 7 13 7 0 0 0 0 % L
% Met: 0 0 0 7 0 0 7 13 0 0 0 0 0 0 0 % M
% Asn: 7 0 7 69 13 0 0 0 0 0 7 0 57 13 0 % N
% Pro: 0 0 0 0 0 7 0 0 0 0 7 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 7 0 0 0 7 0 0 0 0 0 0 7 63 % R
% Ser: 82 25 69 13 0 0 0 0 0 0 0 7 0 13 0 % S
% Thr: 0 0 0 0 0 0 0 7 7 0 0 0 7 0 0 % T
% Val: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % W
% Tyr: 0 0 0 0 7 69 19 63 13 0 7 0 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _