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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IDH1 All Species: 49.7
Human Site: Y235 Identified Species: 91.11
UniProt: O75874 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75874 NP_005887.2 414 46659 Y235 Q E I Y D K Q Y K S Q F E A Q
Chimpanzee Pan troglodytes XP_001141655 414 46695 Y235 Q E I Y D K R Y K S Q F E A Q
Rhesus Macaque Macaca mulatta XP_001107627 414 46656 Y235 Q E I Y D K Q Y K S Q F E A Q
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus O88844 414 46642 Y235 Q E I Y D K K Y K S Q F E A Q
Rat Rattus norvegicus P41562 414 46716 Y235 Q E I Y D K Q Y K S K F E A Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511049 415 46679 Y235 Q E I Y E K Q Y R S K F E A K
Chicken Gallus gallus XP_421965 415 46584 Y235 Q E I Y D R E Y K S Q F E A K
Frog Xenopus laevis NP_001088022 415 46831 Y235 Q E I Y E K E Y K S Q F E E N
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_652044 469 52571 Y286 E D L Y N K Q Y K K E Y E A A
Honey Bee Apis mellifera XP_623673 409 46628 Y232 H E I Y E K E Y K A Q F E A K
Nematode Worm Caenorhab. elegans NP_501665 412 45941 Y234 F A E I Y P E Y E A E F K A A
Sea Urchin Strong. purpuratus XP_780121 409 45854 Y234 Q E I Y E K E Y R A D Y E A K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P21954 428 48172 Y252 Q E V Y E A Q Y K S K F E Q L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 99 N.A. N.A. 95.4 96.3 N.A. 90.1 89.4 87.9 N.A. N.A. 64.1 73.4 75.3 73.6
Protein Similarity: 100 100 99.5 N.A. N.A. 97.8 98.5 N.A. 95.4 94.9 94.6 N.A. N.A. 76.5 86.4 85.7 87.9
P-Site Identity: 100 93.3 100 N.A. N.A. 93.3 93.3 N.A. 73.3 80 73.3 N.A. N.A. 46.6 66.6 20 53.3
P-Site Similarity: 100 100 100 N.A. N.A. 100 100 N.A. 100 100 86.6 N.A. N.A. 86.6 93.3 53.3 93.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 64 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 78 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 60 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 80 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 0 8 0 0 0 24 0 0 0 85 16 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 0 47 0 0 0 0 0 8 0 0 0 0 % D
% Glu: 8 85 8 0 39 0 39 0 8 0 16 0 93 8 0 % E
% Phe: 8 0 0 0 0 0 0 0 0 0 0 85 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 77 8 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 77 8 0 77 8 24 0 8 0 31 % K
% Leu: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 8 % N
% Pro: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % P
% Gln: 77 0 0 0 0 0 47 0 0 0 54 0 0 8 39 % Q
% Arg: 0 0 0 0 0 8 8 0 16 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 0 0 70 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 93 8 0 0 100 0 0 0 16 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _