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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IDH1
All Species:
48.18
Human Site:
Y391
Identified Species:
88.33
UniProt:
O75874
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75874
NP_005887.2
414
46659
Y391
P
N
V
Q
R
S
D
Y
L
N
T
F
E
F
M
Chimpanzee
Pan troglodytes
XP_001141655
414
46695
Y391
P
N
V
Q
R
S
D
Y
L
N
T
F
E
F
M
Rhesus Macaque
Macaca mulatta
XP_001107627
414
46656
Y391
P
N
V
Q
R
S
D
Y
L
N
T
F
E
F
M
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O88844
414
46642
Y391
P
N
V
Q
R
S
D
Y
L
N
T
F
E
F
M
Rat
Rattus norvegicus
P41562
414
46716
Y391
P
N
V
Q
R
S
D
Y
L
N
T
F
E
F
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511049
415
46679
Y391
P
N
V
Q
R
S
D
Y
L
N
T
F
E
F
M
Chicken
Gallus gallus
XP_421965
415
46584
Y391
P
N
V
T
R
S
D
Y
L
N
T
F
E
F
M
Frog
Xenopus laevis
NP_001088022
415
46831
Y391
P
N
V
Q
R
G
D
Y
L
S
T
F
E
F
M
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_652044
469
52571
Y443
N
A
V
T
R
R
D
Y
Q
E
T
F
E
F
I
Honey Bee
Apis mellifera
XP_623673
409
46628
Y388
N
N
V
T
R
S
D
Y
L
E
T
F
E
F
I
Nematode Worm
Caenorhab. elegans
NP_501665
412
45941
Y392
S
A
V
T
R
T
D
Y
L
N
T
F
E
F
L
Sea Urchin
Strong. purpuratus
XP_780121
409
45854
Y390
A
N
V
T
R
A
D
Y
V
N
T
F
E
F
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P21954
428
48172
Y406
G
N
N
E
R
S
A
Y
V
T
T
E
E
F
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
99
N.A.
N.A.
95.4
96.3
N.A.
90.1
89.4
87.9
N.A.
N.A.
64.1
73.4
75.3
73.6
Protein Similarity:
100
100
99.5
N.A.
N.A.
97.8
98.5
N.A.
95.4
94.9
94.6
N.A.
N.A.
76.5
86.4
85.7
87.9
P-Site Identity:
100
100
100
N.A.
N.A.
100
100
N.A.
100
93.3
86.6
N.A.
N.A.
53.3
73.3
66.6
66.6
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
100
93.3
93.3
N.A.
N.A.
60
80
80
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
64
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
78
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
16
0
0
0
8
8
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
93
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
8
0
0
0
0
0
16
0
8
100
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
93
0
100
0
% F
% Gly:
8
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
24
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
77
0
0
0
0
0
16
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
62
% M
% Asn:
16
85
8
0
0
0
0
0
0
70
0
0
0
0
0
% N
% Pro:
62
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
54
0
0
0
0
8
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
100
8
0
0
0
0
0
0
0
0
0
% R
% Ser:
8
0
0
0
0
70
0
0
0
8
0
0
0
0
0
% S
% Thr:
0
0
0
39
0
8
0
0
0
8
100
0
0
0
0
% T
% Val:
0
0
93
0
0
0
0
0
16
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
100
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _