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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SCO1 All Species: 8.48
Human Site: T64 Identified Species: 14.36
UniProt: O75880 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75880 NP_004580.1 301 33814 T64 R P G Y C L G T R P L S T A R
Chimpanzee Pan troglodytes XP_001164786 301 33690 T64 R P G Y C L G T R P L S T A R
Rhesus Macaque Macaca mulatta XP_001118271 301 33849 P64 G Y C L G T R P L S T A R P P
Dog Lupus familis XP_546624 394 43433 S157 G R G G R R V S T A M P P P P
Cat Felis silvestris
Mouse Mus musculus Q5SUC9 284 31599 A47 C S C L R S R A F S A G P P P
Rat Rattus norvegicus NP_001166845 284 31750 N47 R C S L G S R N F S A R P P P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_423738 161 18098
Frog Xenopus laevis NP_001108271 275 31026 H36 R S P S L S R H V P Q S K S F
Zebra Danio Brachydanio rerio Q5RH02 279 32092 T33 I S N H I P N T T C R S S A P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_608884 251 28157 G33 A P A D S T K G K G P I S W R
Honey Bee Apis mellifera XP_001122061 262 30294 G33 V T L E D R K G N R K S F I T
Nematode Worm Caenorhab. elegans NP_494755 312 35631 S65 I T E T E T T S S P K E P P V
Sea Urchin Strong. purpuratus XP_797763 313 34510 S73 F P R P T S V S Q S P Y P Q H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P23833 295 33147 P52 K K P L S R V P V G G T P I K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.6 94.3 59.6 N.A. 70.4 69 N.A. N.A. 41.5 40.2 41.2 N.A. 45.8 39.8 34.9 45.6
Protein Similarity: 100 99 96 64.9 N.A. 77 76.4 N.A. N.A. 48.8 55.1 57.8 N.A. 61.4 60.4 55.1 61.9
P-Site Identity: 100 100 0 6.6 N.A. 0 6.6 N.A. N.A. 0 20 20 N.A. 13.3 6.6 6.6 6.6
P-Site Similarity: 100 100 6.6 20 N.A. 0 6.6 N.A. N.A. 0 26.6 33.3 N.A. 26.6 6.6 13.3 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 34.8 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 52.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 8 0 0 0 0 8 0 8 15 8 0 22 0 % A
% Cys: 8 8 15 0 15 0 0 0 0 8 0 0 0 0 0 % C
% Asp: 0 0 0 8 8 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 8 8 8 0 0 0 0 0 0 8 0 0 0 % E
% Phe: 8 0 0 0 0 0 0 0 15 0 0 0 8 0 8 % F
% Gly: 15 0 22 8 15 0 15 15 0 15 8 8 0 0 0 % G
% His: 0 0 0 8 0 0 0 8 0 0 0 0 0 0 8 % H
% Ile: 15 0 0 0 8 0 0 0 0 0 0 8 0 15 0 % I
% Lys: 8 8 0 0 0 0 15 0 8 0 15 0 8 0 8 % K
% Leu: 0 0 8 29 8 15 0 0 8 0 15 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % M
% Asn: 0 0 8 0 0 0 8 8 8 0 0 0 0 0 0 % N
% Pro: 0 29 15 8 0 8 0 15 0 29 15 8 43 36 36 % P
% Gln: 0 0 0 0 0 0 0 0 8 0 8 0 0 8 0 % Q
% Arg: 29 8 8 0 15 22 29 0 15 8 8 8 8 0 22 % R
% Ser: 0 22 8 8 15 29 0 22 8 29 0 36 15 8 0 % S
% Thr: 0 15 0 8 8 22 8 22 15 0 8 8 15 0 8 % T
% Val: 8 0 0 0 0 0 22 0 15 0 0 0 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % W
% Tyr: 0 8 0 15 0 0 0 0 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _