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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP7B1
All Species:
12.73
Human Site:
S149
Identified Species:
28
UniProt:
O75881
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75881
NP_004811.1
506
58256
S149
Y
Q
F
L
Q
G
K
S
L
D
I
L
L
E
S
Chimpanzee
Pan troglodytes
XP_001159731
506
58281
S149
Y
Q
F
L
Q
G
K
S
L
D
I
L
L
E
S
Rhesus Macaque
Macaca mulatta
XP_001098766
558
64044
S202
Y
Q
F
L
Q
G
K
S
L
D
I
L
L
E
S
Dog
Lupus familis
XP_544102
558
64067
S201
Y
H
L
L
Q
G
K
S
L
D
V
L
T
E
T
Cat
Felis silvestris
Mouse
Mus musculus
Q60991
507
58399
P147
Y
L
L
L
Q
G
K
P
L
D
A
L
L
E
T
Rat
Rattus norvegicus
Q63688
414
48208
C89
T
A
R
V
F
D
F
C
S
S
L
V
F
E
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512397
571
66419
P142
F
R
Y
L
Q
G
K
P
L
D
K
L
V
S
Q
Chicken
Gallus gallus
XP_418276
818
92343
P457
Y
Q
Y
L
Q
G
K
P
L
E
I
I
S
D
H
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_699028
504
58566
A136
Y
T
L
L
Q
G
P
A
L
D
P
L
T
F
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VMT6
501
58204
A150
L
S
P
N
R
V
K
A
V
Y
P
V
S
Q
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O65790
500
57537
E148
F
Q
H
I
R
K
D
E
I
L
R
M
L
T
R
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
84.9
64.3
N.A.
64.8
52.7
N.A.
43.4
34.3
N.A.
42.4
N.A.
20.1
N.A.
N.A.
N.A.
Protein Similarity:
100
99.8
86.9
75.8
N.A.
79.4
67.5
N.A.
59.7
46
N.A.
61.8
N.A.
37.3
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
66.6
N.A.
66.6
6.6
N.A.
46.6
53.3
N.A.
53.3
N.A.
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
80
N.A.
73.3
26.6
N.A.
73.3
80
N.A.
60
N.A.
46.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.3
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
0
0
19
0
0
10
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
10
10
0
0
64
0
0
0
10
0
% D
% Glu:
0
0
0
0
0
0
0
10
0
10
0
0
0
55
0
% E
% Phe:
19
0
28
0
10
0
10
0
0
0
0
0
10
10
0
% F
% Gly:
0
0
0
0
0
73
0
0
0
0
0
0
0
0
0
% G
% His:
0
10
10
0
0
0
0
0
0
0
0
0
0
0
10
% H
% Ile:
0
0
0
10
0
0
0
0
10
0
37
10
0
0
10
% I
% Lys:
0
0
0
0
0
10
73
0
0
0
10
0
0
0
0
% K
% Leu:
10
10
28
73
0
0
0
0
73
10
10
64
46
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% M
% Asn:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
10
0
0
0
10
28
0
0
19
0
0
0
0
% P
% Gln:
0
46
0
0
73
0
0
0
0
0
0
0
0
10
10
% Q
% Arg:
0
10
10
0
19
0
0
0
0
0
10
0
0
0
10
% R
% Ser:
0
10
0
0
0
0
0
37
10
10
0
0
19
10
46
% S
% Thr:
10
10
0
0
0
0
0
0
0
0
0
0
19
10
19
% T
% Val:
0
0
0
10
0
10
0
0
10
0
10
19
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
64
0
19
0
0
0
0
0
0
10
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _