KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP7B1
All Species:
19.7
Human Site:
S250
Identified Species:
43.33
UniProt:
O75881
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75881
NP_004811.1
506
58256
S250
E
K
I
I
K
C
F
S
S
E
K
L
A
K
M
Chimpanzee
Pan troglodytes
XP_001159731
506
58281
S250
E
K
I
I
K
C
F
S
S
E
K
L
A
K
M
Rhesus Macaque
Macaca mulatta
XP_001098766
558
64044
S302
K
K
I
I
K
C
L
S
S
E
N
L
A
K
M
Dog
Lupus familis
XP_544102
558
64067
A302
K
K
L
I
K
H
L
A
S
E
H
L
G
K
T
Cat
Felis silvestris
Mouse
Mus musculus
Q60991
507
58399
T248
K
K
I
I
K
C
L
T
S
E
K
V
A
Q
M
Rat
Rattus norvegicus
Q63688
414
48208
A189
H
E
E
F
E
I
G
A
H
H
L
G
L
L
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512397
571
66419
T243
E
F
L
I
R
Q
F
T
P
E
L
M
V
K
R
Chicken
Gallus gallus
XP_418276
818
92343
L558
K
E
L
I
H
H
F
L
L
Q
N
M
T
K
W
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_699028
504
58566
Y237
E
K
L
I
H
F
F
Y
P
Q
R
M
M
E
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VMT6
501
58204
V253
F
F
N
K
E
T
E
V
F
F
L
D
I
I
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O65790
500
57537
S249
E
V
K
A
I
G
K
S
M
D
D
I
L
Q
R
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
84.9
64.3
N.A.
64.8
52.7
N.A.
43.4
34.3
N.A.
42.4
N.A.
20.1
N.A.
N.A.
N.A.
Protein Similarity:
100
99.8
86.9
75.8
N.A.
79.4
67.5
N.A.
59.7
46
N.A.
61.8
N.A.
37.3
N.A.
N.A.
N.A.
P-Site Identity:
100
100
80
46.6
N.A.
66.6
0
N.A.
33.3
20
N.A.
26.6
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
86.6
66.6
N.A.
93.3
20
N.A.
60
53.3
N.A.
60
N.A.
6.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.3
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
0
0
0
19
0
0
0
0
37
0
0
% A
% Cys:
0
0
0
0
0
37
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
10
10
10
0
0
0
% D
% Glu:
46
19
10
0
19
0
10
0
0
55
0
0
0
10
0
% E
% Phe:
10
19
0
10
0
10
46
0
10
10
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
10
10
0
0
0
0
10
10
0
0
% G
% His:
10
0
0
0
19
19
0
0
10
10
10
0
0
0
0
% H
% Ile:
0
0
37
73
10
10
0
0
0
0
0
10
10
10
0
% I
% Lys:
37
55
10
10
46
0
10
0
0
0
28
0
0
55
0
% K
% Leu:
0
0
37
0
0
0
28
10
10
0
28
37
19
10
0
% L
% Met:
0
0
0
0
0
0
0
0
10
0
0
28
10
0
37
% M
% Asn:
0
0
10
0
0
0
0
0
0
0
19
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
19
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
10
0
0
0
19
0
0
0
19
0
% Q
% Arg:
0
0
0
0
10
0
0
0
0
0
10
0
0
0
28
% R
% Ser:
0
0
0
0
0
0
0
37
46
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
10
0
19
0
0
0
0
10
0
10
% T
% Val:
0
10
0
0
0
0
0
10
0
0
0
10
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
28
% W
% Tyr:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _