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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CYP7B1 All Species: 8.18
Human Site: T40 Identified Species: 18
UniProt: O75881 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.4
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75881 NP_004811.1 506 58256 T40 L C L L V R R T R R P G E P P
Chimpanzee Pan troglodytes XP_001159731 506 58281 T40 L C L L V R R T R R P G E P P
Rhesus Macaque Macaca mulatta XP_001098766 558 64044 R93 Q G L P S R V R G R P G E P P
Dog Lupus familis XP_544102 558 64067 P93 G C D E Q I S P R R P G E P P
Cat Felis silvestris
Mouse Mus musculus Q60991 507 58399 T38 L F L L T R R T R R P R E P P
Rat Rattus norvegicus Q63688 414 48208
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512397 571 66419 F33 E Q V F Q F K F W R P K E P P
Chicken Gallus gallus XP_418276 818 92343 K346 V C V L C R R K R K T G E P P
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_699028 504 58566 G29 C G R R R K D G E P P L I K G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VMT6 501 58204 R30 T W N F N Y W R K R G I K T A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O65790 500 57537 R35 L P P G P P S R P F V G H L H
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 84.9 64.3 N.A. 64.8 52.7 N.A. 43.4 34.3 N.A. 42.4 N.A. 20.1 N.A. N.A. N.A.
Protein Similarity: 100 99.8 86.9 75.8 N.A. 79.4 67.5 N.A. 59.7 46 N.A. 61.8 N.A. 37.3 N.A. N.A. N.A.
P-Site Identity: 100 100 53.3 53.3 N.A. 80 0 N.A. 33.3 60 N.A. 6.6 N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 100 53.3 53.3 N.A. 80 0 N.A. 46.6 80 N.A. 13.3 N.A. 20 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 20.3 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 39.5 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % A
% Cys: 10 37 0 0 10 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 10 0 0 0 10 0 0 0 0 0 0 0 0 % D
% Glu: 10 0 0 10 0 0 0 0 10 0 0 0 64 0 0 % E
% Phe: 0 10 0 19 0 10 0 10 0 10 0 0 0 0 0 % F
% Gly: 10 19 0 10 0 0 0 10 10 0 10 55 0 0 10 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 10 % H
% Ile: 0 0 0 0 0 10 0 0 0 0 0 10 10 0 0 % I
% Lys: 0 0 0 0 0 10 10 10 10 10 0 10 10 10 0 % K
% Leu: 37 0 37 37 0 0 0 0 0 0 0 10 0 10 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 10 0 10 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 10 10 10 10 10 0 10 10 10 64 0 0 64 64 % P
% Gln: 10 10 0 0 19 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 10 10 10 46 37 28 46 64 0 10 0 0 0 % R
% Ser: 0 0 0 0 10 0 19 0 0 0 0 0 0 0 0 % S
% Thr: 10 0 0 0 10 0 0 28 0 0 10 0 0 10 0 % T
% Val: 10 0 19 0 19 0 10 0 0 0 10 0 0 0 0 % V
% Trp: 0 10 0 0 0 0 10 0 10 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _