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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP7B1
All Species:
24.55
Human Site:
Y274
Identified Species:
54
UniProt:
O75881
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75881
NP_004811.1
506
58256
Y274
R
Q
D
V
L
E
K
Y
Y
V
H
E
D
L
E
Chimpanzee
Pan troglodytes
XP_001159731
506
58281
Y274
R
Q
D
V
L
E
K
Y
Y
V
H
E
D
L
E
Rhesus Macaque
Macaca mulatta
XP_001098766
558
64044
Y326
R
Q
D
V
L
E
K
Y
Y
V
H
E
D
L
E
Dog
Lupus familis
XP_544102
558
64067
Y326
R
Q
D
V
L
E
K
Y
Y
T
L
E
D
F
E
Cat
Felis silvestris
Mouse
Mus musculus
Q60991
507
58399
Y272
S
Q
D
L
L
K
R
Y
Y
R
H
D
D
S
E
Rat
Rattus norvegicus
Q63688
414
48208
L213
M
F
W
A
M
Y
Y
L
L
Q
H
P
E
A
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512397
571
66419
Y267
R
R
E
F
L
E
K
Y
K
L
L
Q
D
Y
S
Chicken
Gallus gallus
XP_418276
818
92343
Y582
R
Q
D
I
F
E
K
Y
E
L
L
G
D
Y
D
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_699028
504
58566
Y261
R
T
A
L
F
Q
D
Y
D
T
L
Q
D
R
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VMT6
501
58204
F277
P
E
Q
Q
R
D
D
F
L
N
Y
M
L
Q
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O65790
500
57537
H273
E
G
N
T
M
V
N
H
L
I
S
L
Q
Q
Q
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
84.9
64.3
N.A.
64.8
52.7
N.A.
43.4
34.3
N.A.
42.4
N.A.
20.1
N.A.
N.A.
N.A.
Protein Similarity:
100
99.8
86.9
75.8
N.A.
79.4
67.5
N.A.
59.7
46
N.A.
61.8
N.A.
37.3
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
80
N.A.
53.3
6.6
N.A.
40
46.6
N.A.
20
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
80
N.A.
80
20
N.A.
66.6
66.6
N.A.
46.6
N.A.
26.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.3
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
10
0
0
0
0
0
0
0
0
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
55
0
0
10
19
0
10
0
0
10
73
0
19
% D
% Glu:
10
10
10
0
0
55
0
0
10
0
0
37
10
0
46
% E
% Phe:
0
10
0
10
19
0
0
10
0
0
0
0
0
10
0
% F
% Gly:
0
10
0
0
0
0
0
0
0
0
0
10
0
0
0
% G
% His:
0
0
0
0
0
0
0
10
0
0
46
0
0
0
0
% H
% Ile:
0
0
0
10
0
0
0
0
0
10
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
10
55
0
10
0
0
0
0
0
0
% K
% Leu:
0
0
0
19
55
0
0
10
28
19
37
10
10
28
10
% L
% Met:
10
0
0
0
19
0
0
0
0
0
0
10
0
0
10
% M
% Asn:
0
0
10
0
0
0
10
0
0
10
0
0
0
0
0
% N
% Pro:
10
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% P
% Gln:
0
55
10
10
0
10
0
0
0
10
0
19
10
19
10
% Q
% Arg:
64
10
0
0
10
0
10
0
0
10
0
0
0
10
0
% R
% Ser:
10
0
0
0
0
0
0
0
0
0
10
0
0
10
10
% S
% Thr:
0
10
0
10
0
0
0
0
0
19
0
0
0
0
0
% T
% Val:
0
0
0
37
0
10
0
0
0
28
0
0
0
0
0
% V
% Trp:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
10
10
73
46
0
10
0
0
19
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _