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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ALDH1L1 All Species: 38.79
Human Site: S350 Identified Species: 56.89
UniProt: O75891 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75891 NP_036322.2 902 98829 S350 D S T D F F K S G A A S V D V
Chimpanzee Pan troglodytes XP_516714 1144 124371 S589 D S T D F F K S G A A S V D V
Rhesus Macaque Macaca mulatta XP_001108084 1077 117462 S525 D S T D F F K S G A A S V D V
Dog Lupus familis XP_533713 902 98867 S350 E S T D F F K S G A A S V D V
Cat Felis silvestris
Mouse Mus musculus Q8R0Y6 902 98691 S350 D S T D F F K S G A A S V D V
Rat Rattus norvegicus P28037 902 99108 S350 D S T D F F K S G A A S V D V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505782 1010 111425 S458 G A T D F F K S G A S S M D V
Chicken Gallus gallus O93344 518 56713 H24 A A L M A S L H L L P S P T L
Frog Xenopus laevis Q6GNL7 902 99964 A350 D S T D F F K A G A A S M D V
Zebra Danio Brachydanio rerio XP_001334699 903 100163 S351 D T T D F F K S G A A S M D V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_610107 913 100280 S359 S S T D F F A S G A G S M D V
Honey Bee Apis mellifera XP_623798 900 99997 A352 T D F F A C G A G S M D V I R
Nematode Worm Caenorhab. elegans NP_502054 908 99259 S358 S D T D F F E S G A S S A D V
Sea Urchin Strong. purpuratus XP_784777 884 96767 M350 G D T D F F K M G A G S M D V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SU63 538 58570 A44 R F G T S S A A A E E I I N P
Baker's Yeast Sacchar. cerevisiae P40047 520 56602 A26 L L R L Y S Q A P L R V P I T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 76.4 81.6 92.2 N.A. 92.3 91.2 N.A. 66.4 31.1 77.8 76.5 N.A. 60.2 59.4 59.2 66.7
Protein Similarity: 100 77.1 83 96.6 N.A. 96.7 96.4 N.A. 78.5 41.7 89.5 88.1 N.A. 74.6 76.9 74.8 78.7
P-Site Identity: 100 100 100 93.3 N.A. 100 100 N.A. 73.3 6.6 86.6 86.6 N.A. 73.3 13.3 66.6 66.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 93.3 20 100 100 N.A. 80 26.6 80 73.3
Percent
Protein Identity: N.A. N.A. N.A. 28.4 29 N.A.
Protein Similarity: N.A. N.A. N.A. 41.3 41.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 13 0 0 13 0 13 25 7 75 50 0 7 0 0 % A
% Cys: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % C
% Asp: 44 19 0 75 0 0 0 0 0 0 0 7 0 75 0 % D
% Glu: 7 0 0 0 0 0 7 0 0 7 7 0 0 0 0 % E
% Phe: 0 7 7 7 75 75 0 0 0 0 0 0 0 0 0 % F
% Gly: 13 0 7 0 0 0 7 0 82 0 13 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 7 7 13 0 % I
% Lys: 0 0 0 0 0 0 63 0 0 0 0 0 0 0 0 % K
% Leu: 7 7 7 7 0 0 7 0 7 13 0 0 0 0 7 % L
% Met: 0 0 0 7 0 0 0 7 0 0 7 0 32 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % N
% Pro: 0 0 0 0 0 0 0 0 7 0 7 0 13 0 7 % P
% Gln: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % Q
% Arg: 7 0 7 0 0 0 0 0 0 0 7 0 0 0 7 % R
% Ser: 13 50 0 0 7 19 0 63 0 7 13 82 0 0 0 % S
% Thr: 7 7 75 7 0 0 0 0 0 0 0 0 0 7 7 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 7 44 0 75 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _