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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DGAT1 All Species: 29.7
Human Site: Y477 Identified Species: 59.39
UniProt: O75907 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75907 NP_036211.2 488 55278 Y477 L M Y V H D Y Y V L N Y E A P
Chimpanzee Pan troglodytes XP_520014 488 54742 Y477 L M Y V H D Y Y V L N Y E A P
Rhesus Macaque Macaca mulatta XP_001090134 491 55617 Y480 L M Y V H D Y Y V L N Y E A P
Dog Lupus familis XP_849176 498 56652 Y487 L M Y V H D Y Y V L H Y E A P
Cat Felis silvestris
Mouse Mus musculus Q9Z2A7 498 56772 Y488 L M Y V H D Y Y V L N Y D A P
Rat Rattus norvegicus Q9ERM3 498 56852 Y488 L M Y V H D Y Y V L N Y D A P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_956024 499 57133 Y486 L M Y V H D Y Y V L H Y G S A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609813 565 64925 V550 M A Y Y H D Y V V Q H F K N S
Honey Bee Apis mellifera XP_624754 498 58148 V483 M M Y Y H D Y V I T H F G E N
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_780515 485 56246 Y470 L M Y F H D Y Y V M H A A I N
Poplar Tree Populus trichocarpa XP_002330510 493 56790 L477 L G Q P M C V L L Y Y H D L M
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P53629 642 74004 P632 W L G I C M G P S V M C T L Y
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.2 96.3 86.5 N.A. 84.7 84.7 N.A. N.A. N.A. N.A. 62.5 N.A. 37.1 35.9 N.A. 35.8
Protein Similarity: 100 96.3 97.5 89.7 N.A. 90.3 90.3 N.A. N.A. N.A. N.A. 74.5 N.A. 55.2 52 N.A. 53.2
P-Site Identity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. N.A. N.A. N.A. 73.3 N.A. 33.3 33.3 N.A. 53.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. N.A. N.A. 86.6 N.A. 60 60 N.A. 66.6
Percent
Protein Identity: 36.1 N.A. N.A. N.A. 23.2 N.A.
Protein Similarity: 54.9 N.A. N.A. N.A. 41.4 N.A.
P-Site Identity: 6.6 N.A. N.A. N.A. 0 N.A.
P-Site Similarity: 26.6 N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 0 0 0 0 0 0 0 0 0 9 9 50 9 % A
% Cys: 0 0 0 0 9 9 0 0 0 0 0 9 0 0 0 % C
% Asp: 0 0 0 0 0 84 0 0 0 0 0 0 25 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 34 9 0 % E
% Phe: 0 0 0 9 0 0 0 0 0 0 0 17 0 0 0 % F
% Gly: 0 9 9 0 0 0 9 0 0 0 0 0 17 0 0 % G
% His: 0 0 0 0 84 0 0 0 0 0 42 9 0 0 0 % H
% Ile: 0 0 0 9 0 0 0 0 9 0 0 0 0 9 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % K
% Leu: 75 9 0 0 0 0 0 9 9 59 0 0 0 17 0 % L
% Met: 17 75 0 0 9 9 0 0 0 9 9 0 0 0 9 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 42 0 0 9 17 % N
% Pro: 0 0 0 9 0 0 0 9 0 0 0 0 0 0 50 % P
% Gln: 0 0 9 0 0 0 0 0 0 9 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 0 9 0 0 0 0 9 9 % S
% Thr: 0 0 0 0 0 0 0 0 0 9 0 0 9 0 0 % T
% Val: 0 0 0 59 0 0 9 17 75 9 0 0 0 0 0 % V
% Trp: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 84 17 0 0 84 67 0 9 9 59 0 0 9 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _