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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DGKI
All Species:
22.42
Human Site:
Y400
Identified Species:
41.11
UniProt:
O75912
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75912
NP_004708.1
1065
116997
Y400
V
L
Q
M
F
M
W
Y
L
N
P
R
Q
V
F
Chimpanzee
Pan troglodytes
XP_001147695
1066
117064
Y401
V
L
Q
M
F
M
W
Y
L
N
P
R
Q
V
F
Rhesus Macaque
Macaca mulatta
XP_001107030
1066
117055
Y401
V
L
Q
M
F
M
W
Y
L
N
P
R
Q
V
F
Dog
Lupus familis
XP_539825
1017
113427
Y360
V
L
Q
M
F
M
W
Y
L
N
P
R
Q
V
F
Cat
Felis silvestris
Mouse
Mus musculus
Q80UP3
929
104029
L329
N
P
R
Q
V
F
D
L
S
Q
G
G
P
R
E
Rat
Rattus norvegicus
O08560
929
103991
L329
N
P
R
Q
V
F
D
L
S
Q
G
G
P
R
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513139
955
107141
L338
P
P
V
G
V
L
P
L
G
T
G
N
D
L
A
Chicken
Gallus gallus
XP_416357
1074
118933
Y401
V
L
Q
M
F
M
W
Y
L
N
P
R
Q
V
F
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001922445
1086
121319
Y387
I
I
Q
T
F
L
W
Y
L
N
P
R
Q
V
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q09103
1457
160124
L836
L
L
G
K
F
Q
H
L
L
N
P
R
Q
V
F
Honey Bee
Apis mellifera
XP_396522
837
92900
L237
K
V
P
N
L
R
V
L
A
C
G
G
D
G
T
Nematode Worm
Caenorhab. elegans
Q10024
937
105180
I336
G
K
E
K
K
E
T
I
A
V
T
C
S
W
C
Sea Urchin
Strong. purpuratus
XP_796061
815
92455
K215
Q
Q
K
L
F
Q
Q
K
D
I
I
A
I
S
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.4
86.4
N.A.
55.5
56.6
N.A.
75.4
80.7
N.A.
56.6
N.A.
31.6
34.1
34
43.3
Protein Similarity:
100
99.9
99.6
89.1
N.A.
69.3
69.3
N.A.
80.9
86.4
N.A.
69.1
N.A.
44.5
49.4
49.6
55.9
P-Site Identity:
100
100
100
100
N.A.
0
0
N.A.
0
100
N.A.
73.3
N.A.
60
0
0
6.6
P-Site Similarity:
100
100
100
100
N.A.
6.6
6.6
N.A.
13.3
100
N.A.
93.3
N.A.
66.6
6.6
6.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
16
0
0
8
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
8
0
8
0
0
16
% C
% Asp:
0
0
0
0
0
0
16
0
8
0
0
0
16
0
0
% D
% Glu:
0
0
8
0
0
8
0
0
0
0
0
0
0
0
16
% E
% Phe:
0
0
0
0
62
16
0
0
0
0
0
0
0
0
54
% F
% Gly:
8
0
8
8
0
0
0
0
8
0
31
24
0
8
0
% G
% His:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
8
8
0
0
0
0
0
8
0
8
8
0
8
0
0
% I
% Lys:
8
8
8
16
8
0
0
8
0
0
0
0
0
0
0
% K
% Leu:
8
47
0
8
8
16
0
39
54
0
0
0
0
8
0
% L
% Met:
0
0
0
39
0
39
0
0
0
0
0
0
0
0
0
% M
% Asn:
16
0
0
8
0
0
0
0
0
54
0
8
0
0
0
% N
% Pro:
8
24
8
0
0
0
8
0
0
0
54
0
16
0
0
% P
% Gln:
8
8
47
16
0
16
8
0
0
16
0
0
54
0
0
% Q
% Arg:
0
0
16
0
0
8
0
0
0
0
0
54
0
16
0
% R
% Ser:
0
0
0
0
0
0
0
0
16
0
0
0
8
8
0
% S
% Thr:
0
0
0
8
0
0
8
0
0
8
8
0
0
0
8
% T
% Val:
39
8
8
0
24
0
8
0
0
8
0
0
0
54
0
% V
% Trp:
0
0
0
0
0
0
47
0
0
0
0
0
0
8
0
% W
% Tyr:
0
0
0
0
0
0
0
47
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _