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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PAK3
All Species:
31.82
Human Site:
S259
Identified Species:
58.33
UniProt:
O75914
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75914
NP_001121638.1
559
62310
S259
T
D
R
Q
R
K
K
S
K
M
T
D
E
E
I
Chimpanzee
Pan troglodytes
NP_001009039
559
62291
S259
T
D
R
Q
R
K
K
S
K
M
T
D
E
E
I
Rhesus Macaque
Macaca mulatta
XP_001100151
563
62483
S259
T
D
R
Q
R
K
K
S
K
M
T
D
E
E
I
Dog
Lupus familis
XP_851348
559
62265
S259
T
D
R
Q
R
K
K
S
K
M
T
D
E
E
I
Cat
Felis silvestris
Mouse
Mus musculus
Q61036
559
62379
S259
T
D
R
Q
R
K
K
S
K
M
T
D
E
E
I
Rat
Rattus norvegicus
Q62829
544
60692
S244
T
D
R
Q
R
K
K
S
K
M
T
D
E
E
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_420314
543
60608
S243
T
D
R
Q
R
K
K
S
K
M
T
D
E
E
I
Frog
Xenopus laevis
NP_001079232
564
62749
S264
T
D
R
Q
R
K
K
S
K
M
T
D
E
E
I
Zebra Danio
Brachydanio rerio
NP_958485
577
63243
K278
T
T
D
K
S
R
K
K
K
M
S
D
E
E
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VXE5
639
69601
Q344
A
G
Q
P
K
Q
D
Q
R
L
T
H
E
Q
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17850
572
63863
K271
A
R
G
Q
K
A
K
K
K
M
T
D
A
E
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q03497
939
102344
R596
N
E
K
K
R
E
E
R
E
R
R
K
K
Q
L
Red Bread Mold
Neurospora crassa
Q7RZD3
954
103773
R650
A
R
P
R
H
R
P
R
Q
S
N
A
I
D
V
Conservation
Percent
Protein Identity:
100
100
93.7
99.1
N.A.
98.5
96
N.A.
N.A.
93.5
93.7
78.1
N.A.
33
N.A.
50.8
N.A.
Protein Similarity:
100
100
95.9
99.4
N.A.
99.1
96.5
N.A.
N.A.
95.1
95.9
83.3
N.A.
50.8
N.A.
65
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
100
53.3
N.A.
13.3
N.A.
46.6
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
100
73.3
N.A.
53.3
N.A.
60
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
31.6
30.9
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
43.2
44
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
0
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
66.6
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
24
0
0
0
0
8
0
0
0
0
0
8
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
62
8
0
0
0
8
0
0
0
0
77
0
8
0
% D
% Glu:
0
8
0
0
0
8
8
0
8
0
0
0
77
77
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
8
8
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
8
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
70
% I
% Lys:
0
0
8
16
16
62
77
16
77
0
0
8
8
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
77
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% N
% Pro:
0
0
8
8
0
0
8
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
70
0
8
0
8
8
0
0
0
0
16
0
% Q
% Arg:
0
16
62
8
70
16
0
16
8
8
8
0
0
0
0
% R
% Ser:
0
0
0
0
8
0
0
62
0
8
8
0
0
0
0
% S
% Thr:
70
8
0
0
0
0
0
0
0
0
77
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _