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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIAS2 All Species: 18.18
Human Site: S599 Identified Species: 33.33
UniProt: O75928 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75928 NP_004662.2 621 68240 S599 S T H V S S S S S R S E T G V
Chimpanzee Pan troglodytes XP_001147441 612 67116 S590 S T H V S S S S S R S E T G V
Rhesus Macaque Macaca mulatta XP_001085703 612 67146 S590 S T H V S S S S S R S E T G V
Dog Lupus familis XP_852829 541 60303 E520 M S S D L P G E Q R R N D I N
Cat Felis silvestris
Mouse Mus musculus Q8C5D8 621 68407 S599 S T H V S S S S S R S E T G V
Rat Rattus norvegicus Q6AZ28 572 63413 E551 M S S D L P G E Q R R N D I N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506015 622 68325 S599 E S T T H V S S S S R S E T G
Chicken Gallus gallus NP_001025797 622 68442 S599 E S N T H V S S S N R S E T G
Frog Xenopus laevis NP_001084972 584 64427 Y562 L V S M D P Q Y Y P P M F L D
Zebra Danio Brachydanio rerio XP_685704 623 69106 S599 Q Y E T A T H S S S S S H E T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q94361 793 89556 L695 L H H T T H P L N F A Q S S Y
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q680Q4 884 97015 D822 S T R E G S M D T T T E T A S
Baker's Yeast Sacchar. cerevisiae Q12216 726 81160 G661 Y I H V S T S G H G D D G K I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.5 98.3 84 N.A. 98 87.5 N.A. 93.8 92.4 74.7 71.5 N.A. N.A. N.A. 23.4 N.A.
Protein Similarity: 100 98.5 98.3 85.6 N.A. 99 90 N.A. 97.1 95.8 84.2 83.3 N.A. N.A. N.A. 39.8 N.A.
P-Site Identity: 100 100 100 6.6 N.A. 100 6.6 N.A. 20 20 0 20 N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: 100 100 100 13.3 N.A. 100 13.3 N.A. 26.6 33.3 6.6 33.3 N.A. N.A. N.A. 40 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 20.3 20.1 N.A.
Protein Similarity: N.A. N.A. N.A. 34.8 38.5 N.A.
P-Site Identity: N.A. N.A. N.A. 33.3 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 46.6 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 8 0 0 0 0 0 8 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 16 8 0 0 8 0 0 8 8 16 0 8 % D
% Glu: 16 0 8 8 0 0 0 16 0 0 0 39 16 8 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 8 0 0 8 0 0 % F
% Gly: 0 0 0 0 8 0 16 8 0 8 0 0 8 31 16 % G
% His: 0 8 47 0 16 8 8 0 8 0 0 0 8 0 0 % H
% Ile: 0 8 0 0 0 0 0 0 0 0 0 0 0 16 8 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % K
% Leu: 16 0 0 0 16 0 0 8 0 0 0 0 0 8 0 % L
% Met: 16 0 0 8 0 0 8 0 0 0 0 8 0 0 0 % M
% Asn: 0 0 8 0 0 0 0 0 8 8 0 16 0 0 16 % N
% Pro: 0 0 0 0 0 24 8 0 0 8 8 0 0 0 0 % P
% Gln: 8 0 0 0 0 0 8 0 16 0 0 8 0 0 0 % Q
% Arg: 0 0 8 0 0 0 0 0 0 47 31 0 0 0 0 % R
% Ser: 39 31 24 0 39 39 54 54 54 16 39 24 8 8 8 % S
% Thr: 0 39 8 31 8 16 0 0 8 8 8 0 39 16 8 % T
% Val: 0 8 0 39 0 16 0 0 0 0 0 0 0 0 31 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 8 0 0 0 0 0 8 8 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _