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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIAS2 All Species: 11.52
Human Site: S81 Identified Species: 21.11
UniProt: O75928 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75928 NP_004662.2 621 68240 S81 D L S T I K S S V F S L D G G
Chimpanzee Pan troglodytes XP_001147441 612 67116 L76 I K S S V F S L D G G S S P V
Rhesus Macaque Macaca mulatta XP_001085703 612 67146 L76 I K S S V F S L D G S S S P V
Dog Lupus familis XP_852829 541 60303 L14 V S E L Q V L L G F A G R N K
Cat Felis silvestris
Mouse Mus musculus Q8C5D8 621 68407 S81 D L S T I K S S V F S L D G S
Rat Rattus norvegicus Q6AZ28 572 63413 L45 L M R A L H L L K S G C T P A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506015 622 68325 S81 D L S T I K P S V F N L D S S
Chicken Gallus gallus NP_001025797 622 68442 A81 D L S A I K P A V F S L D S S
Frog Xenopus laevis NP_001084972 584 64427 K56 C S P A V Q I K I K E L Y C R
Zebra Danio Brachydanio rerio XP_685704 623 69106 S81 D L A A L K S S I K S F I H L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q94361 793 89556 P162 H L Q Q Q H H P S T V R W L T
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q680Q4 884 97015 D93 S K G Q V S S D T S N L K V K
Baker's Yeast Sacchar. cerevisiae Q12216 726 81160 S80 I K Q F L R K S C D I G H I D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.5 98.3 84 N.A. 98 87.5 N.A. 93.8 92.4 74.7 71.5 N.A. N.A. N.A. 23.4 N.A.
Protein Similarity: 100 98.5 98.3 85.6 N.A. 99 90 N.A. 97.1 95.8 84.2 83.3 N.A. N.A. N.A. 39.8 N.A.
P-Site Identity: 100 13.3 20 6.6 N.A. 93.3 0 N.A. 73.3 66.6 6.6 40 N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: 100 26.6 33.3 13.3 N.A. 93.3 13.3 N.A. 80 73.3 26.6 60 N.A. N.A. N.A. 6.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 20.3 20.1 N.A.
Protein Similarity: N.A. N.A. N.A. 34.8 38.5 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 31 0 0 0 8 0 0 8 0 0 0 8 % A
% Cys: 8 0 0 0 0 0 0 0 8 0 0 8 0 8 0 % C
% Asp: 39 0 0 0 0 0 0 8 16 8 0 0 31 0 8 % D
% Glu: 0 0 8 0 0 0 0 0 0 0 8 0 0 0 0 % E
% Phe: 0 0 0 8 0 16 0 0 0 39 0 8 0 0 0 % F
% Gly: 0 0 8 0 0 0 0 0 8 16 16 16 0 16 8 % G
% His: 8 0 0 0 0 16 8 0 0 0 0 0 8 8 0 % H
% Ile: 24 0 0 0 31 0 8 0 16 0 8 0 8 8 0 % I
% Lys: 0 31 0 0 0 39 8 8 8 16 0 0 8 0 16 % K
% Leu: 8 47 0 8 24 0 16 31 0 0 0 47 0 8 8 % L
% Met: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 16 0 0 8 0 % N
% Pro: 0 0 8 0 0 0 16 8 0 0 0 0 0 24 0 % P
% Gln: 0 0 16 16 16 8 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 8 0 0 8 0 0 0 0 0 8 8 0 8 % R
% Ser: 8 16 47 16 0 8 47 39 8 16 39 16 16 16 24 % S
% Thr: 0 0 0 24 0 0 0 0 8 8 0 0 8 0 8 % T
% Val: 8 0 0 0 31 8 0 0 31 0 8 0 0 8 16 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _