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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDKL5 All Species: 3.03
Human Site: S502 Identified Species: 8.33
UniProt: O76039 Number Species: 8
    Phosphosite Substitution
    Charge Score: -0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O76039 NP_001032420.1 1030 115538 S502 S K S V S N L S E A R A Q I A
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta NP_001129485 570 64691 L67 H E N L V N L L E V C K K K K
Dog Lupus familis XP_548881 960 107395 S453 S F M E S S Q S K A G T L Q P
Cat Felis silvestris
Mouse Mus musculus Q3UTQ8 938 105471 K435 G P G T K Y L K S S T R S Q Q
Rat Rattus norvegicus Q5XIT0 507 57117
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514328 967 107039 G453 N R H S L M E G S Q G K T G T
Chicken Gallus gallus XP_425571 960 107495 K454 F M E T S Q S K T G T L Q P G
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001124243 1039 116666 S526 L D D P M A G S G S G S R Y F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796071 627 72401 H124 C H R N D V I H R D N E D V R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 26.7 88.1 N.A. 85.9 23.6 N.A. 76.5 75.2 N.A. 55.3 N.A. N.A. N.A. N.A. 25.5
Protein Similarity: 100 N.A. 39.5 89.7 N.A. 88.9 36.5 N.A. 82.5 83.6 N.A. 69.1 N.A. N.A. N.A. N.A. 39
P-Site Identity: 100 N.A. 20 26.6 N.A. 6.6 0 N.A. 0 13.3 N.A. 6.6 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 N.A. 46.6 40 N.A. 13.3 0 N.A. 13.3 13.3 N.A. 26.6 N.A. N.A. N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 12 0 0 0 23 0 12 0 0 12 % A
% Cys: 12 0 0 0 0 0 0 0 0 0 12 0 0 0 0 % C
% Asp: 0 12 12 0 12 0 0 0 0 12 0 0 12 0 0 % D
% Glu: 0 12 12 12 0 0 12 0 23 0 0 12 0 0 0 % E
% Phe: 12 12 0 0 0 0 0 0 0 0 0 0 0 0 12 % F
% Gly: 12 0 12 0 0 0 12 12 12 12 34 0 0 12 12 % G
% His: 12 12 12 0 0 0 0 12 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 12 0 0 0 0 0 0 12 0 % I
% Lys: 0 12 0 0 12 0 0 23 12 0 0 23 12 12 12 % K
% Leu: 12 0 0 12 12 0 34 12 0 0 0 12 12 0 0 % L
% Met: 0 12 12 0 12 12 0 0 0 0 0 0 0 0 0 % M
% Asn: 12 0 12 12 0 23 0 0 0 0 12 0 0 0 0 % N
% Pro: 0 12 0 12 0 0 0 0 0 0 0 0 0 12 12 % P
% Gln: 0 0 0 0 0 12 12 0 0 12 0 0 23 23 12 % Q
% Arg: 0 12 12 0 0 0 0 0 12 0 12 12 12 0 12 % R
% Ser: 23 0 12 12 34 12 12 34 23 23 0 12 12 0 0 % S
% Thr: 0 0 0 23 0 0 0 0 12 0 23 12 12 0 12 % T
% Val: 0 0 0 12 12 12 0 0 0 12 0 0 0 12 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 12 0 0 0 0 0 0 0 12 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _