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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TM7SF2
All Species:
21.52
Human Site:
S218
Identified Species:
33.81
UniProt:
O76062
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76062
NP_003264.2
418
46406
S218
K
E
A
E
L
R
G
S
P
S
L
A
M
W
L
Chimpanzee
Pan troglodytes
XP_514234
615
70705
V415
M
K
I
Q
D
R
A
V
P
S
L
A
M
I
L
Rhesus Macaque
Macaca mulatta
XP_001118188
516
56907
S316
K
E
A
E
L
R
G
S
P
S
L
A
M
W
L
Dog
Lupus familis
XP_533236
418
46607
S218
Q
E
A
E
L
R
G
S
P
S
L
A
M
W
L
Cat
Felis silvestris
Mouse
Mus musculus
Q71KT5
418
46474
S218
Q
E
A
E
L
R
G
S
P
S
L
A
M
W
L
Rat
Rattus norvegicus
O08984
620
70706
A420
M
K
V
Q
E
R
S
A
P
S
L
A
M
T
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514233
614
70236
S414
M
K
I
Q
N
R
D
S
P
S
L
A
M
I
L
Chicken
Gallus gallus
P23913
637
73480
M408
M
K
I
H
N
Q
S
M
P
S
L
S
M
I
L
Frog
Xenopus laevis
Q7ZXH1
473
54804
Q263
K
Q
Q
E
L
Y
G
Q
V
T
N
S
M
I
L
Zebra Danio
Brachydanio rerio
Q7SXF1
478
55171
Y268
K
Q
Q
E
L
Y
G
Y
V
T
N
S
M
I
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q8MLV1
741
83167
N540
K
Y
Y
W
N
N
V
N
Y
D
P
A
T
L
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786536
578
65964
N378
V
W
T
E
F
P
D
N
P
P
W
N
L
I
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LDR4
369
41895
Q181
S
Q
S
M
I
L
Y
Q
I
F
C
A
L
Y
I
Baker's Yeast
Sacchar. cerevisiae
P32462
438
50597
K242
H
H
Y
L
K
T
G
K
I
N
D
A
L
V
L
Red Bread Mold
Neurospora crassa
P38670
490
54704
Y258
K
Q
Y
R
L
Y
G
Y
V
T
D
S
I
L
F
Conservation
Percent
Protein Identity:
100
40.9
78
91.3
N.A.
86.1
41.4
N.A.
41
39
35.5
33
N.A.
20.9
N.A.
N.A.
39.1
Protein Similarity:
100
52.2
79.2
94.5
N.A.
91.3
51.7
N.A.
51.1
48.9
50.9
50.8
N.A.
33
N.A.
N.A.
48.2
P-Site Identity:
100
46.6
100
93.3
N.A.
93.3
46.6
N.A.
53.3
33.3
40
40
N.A.
13.3
N.A.
N.A.
20
P-Site Similarity:
100
60
100
100
N.A.
100
66.6
N.A.
66.6
53.3
60
60
N.A.
20
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
38
41.5
39.8
Protein Similarity:
N.A.
N.A.
N.A.
54.5
58.4
53.8
P-Site Identity:
N.A.
N.A.
N.A.
6.6
20
20
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
33.3
46.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
27
0
0
0
7
7
0
0
0
67
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% C
% Asp:
0
0
0
0
7
0
14
0
0
7
14
0
0
0
0
% D
% Glu:
0
27
0
47
7
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
7
0
0
0
0
7
0
0
0
0
14
% F
% Gly:
0
0
0
0
0
0
54
0
0
0
0
0
0
0
0
% G
% His:
7
7
0
7
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
20
0
7
0
0
0
14
0
0
0
7
40
7
% I
% Lys:
40
27
0
0
7
0
0
7
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
7
47
7
0
0
0
0
54
0
20
14
80
% L
% Met:
27
0
0
7
0
0
0
7
0
0
0
0
67
0
0
% M
% Asn:
0
0
0
0
20
7
0
14
0
7
14
7
0
0
0
% N
% Pro:
0
0
0
0
0
7
0
0
60
7
7
0
0
0
0
% P
% Gln:
14
27
14
20
0
7
0
14
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
7
0
47
0
0
0
0
0
0
0
0
0
% R
% Ser:
7
0
7
0
0
0
14
34
0
54
0
27
0
0
0
% S
% Thr:
0
0
7
0
0
7
0
0
0
20
0
0
7
7
0
% T
% Val:
7
0
7
0
0
0
7
7
20
0
0
0
0
7
0
% V
% Trp:
0
7
0
7
0
0
0
0
0
0
7
0
0
27
0
% W
% Tyr:
0
7
20
0
0
20
7
14
7
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _