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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CIAO1 All Species: 32.73
Human Site: S110 Identified Species: 48
UniProt: O76071 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O76071 NP_004795.1 339 37840 S110 G H E N E V K S V A W A P S G
Chimpanzee Pan troglodytes XP_001144741 472 51924 S243 G H E N E V K S V A W A P S G
Rhesus Macaque Macaca mulatta XP_001098395 339 37880 S110 G H E N E V K S V A W A P S G
Dog Lupus familis XP_532950 339 37846 S110 G H E N E V K S V A W A P S G
Cat Felis silvestris
Mouse Mus musculus Q99KN2 339 37614 S110 G H E N E V K S V A W A P S G
Rat Rattus norvegicus Q5M7T1 339 37599 S110 G H E N E V K S V A W A P S G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517379 223 24600
Chicken Gallus gallus XP_423992 209 23301
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q6P0D9 330 36784 N106 T V L E G H E N E V K C V A W
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7K1Y4 335 37026 S110 E N E V K S V S W S R S G G L
Honey Bee Apis mellifera XP_395314 332 37365 S108 G H E N E V K S V S W S C S G
Nematode Worm Caenorhab. elegans Q9XW12 337 38172 E111 V N K L E G H E S E V K C A V
Sea Urchin Strong. purpuratus XP_781960 340 38037 V110 H E N E V K S V A W S Q S G S
Poplar Tree Populus trichocarpa XP_002299788 323 35737 V99 L E G H E N E V K C V S W N A
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565615 352 39113 S123 G H E N E V K S V S W N A S G
Baker's Yeast Sacchar. cerevisiae Q05583 330 37256 H106 L L A I I E G H E N E V K G V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 71.8 99.7 97.3 N.A. 94.9 94.4 N.A. 50.1 51.6 N.A. 76.1 N.A. 58.1 58.4 38.6 60
Protein Similarity: 100 71.8 99.7 98.8 N.A. 97.9 97.3 N.A. 54.2 57.5 N.A. 85.8 N.A. 72.2 75.5 57.2 75.8
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 0 0 N.A. 0 N.A. 13.3 80 6.6 0
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 0 0 N.A. 20 N.A. 40 93.3 26.6 0
Percent
Protein Identity: 49.2 N.A. N.A. 48 41.8 N.A.
Protein Similarity: 63.4 N.A. N.A. 64.7 59.8 N.A.
P-Site Identity: 6.6 N.A. N.A. 80 0 N.A.
P-Site Similarity: 33.3 N.A. N.A. 86.6 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 0 0 0 0 0 7 38 0 38 7 13 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 7 0 7 13 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 7 13 57 13 63 7 13 7 13 7 7 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 50 0 7 0 7 7 7 0 0 0 0 0 7 19 50 % G
% His: 7 50 0 7 0 7 7 7 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 7 7 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 7 0 7 7 50 0 7 0 7 7 7 0 0 % K
% Leu: 13 7 7 7 0 0 0 0 0 0 0 0 0 0 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 13 7 50 0 7 0 7 0 7 0 7 0 7 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 38 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % R
% Ser: 0 0 0 0 0 7 7 57 7 19 7 19 7 50 7 % S
% Thr: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 7 7 0 7 7 50 7 13 50 7 13 7 7 0 13 % V
% Trp: 0 0 0 0 0 0 0 0 7 7 50 0 7 0 7 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _