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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CIAO1 All Species: 23.64
Human Site: S199 Identified Species: 34.67
UniProt: O76071 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O76071 NP_004795.1 339 37840 S199 G H E S T V W S L A F D P S G
Chimpanzee Pan troglodytes XP_001144741 472 51924 S332 G H E S T V W S L A F D P S G
Rhesus Macaque Macaca mulatta XP_001098395 339 37880 S199 G H E S T V W S L A F D P S G
Dog Lupus familis XP_532950 339 37846 S199 G H E S T V W S L A F D P S G
Cat Felis silvestris
Mouse Mus musculus Q99KN2 339 37614 S199 G H E S T V W S I A F D P S G
Rat Rattus norvegicus Q5M7T1 339 37599 S199 G H E S T V W S I A F D P S G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517379 223 24600 R88 N L L A T C S R D K S V W V W
Chicken Gallus gallus XP_423992 209 23301 R74 A F D G S G E R L A S C S D D
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q6P0D9 330 36784 S195 A T L E G H E S T V W S L T F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7K1Y4 335 37026 G199 S H T S T V W G I D F D A D G
Honey Bee Apis mellifera XP_395314 332 37365 W197 S S H T S T V W S L A W D K Q
Nematode Worm Caenorhab. elegans Q9XW12 337 38172 H200 Q Q K I D G C H V G T V W S I
Sea Urchin Strong. purpuratus XP_781960 340 38037 A199 G H E S T V W A I S F D K T G
Poplar Tree Populus trichocarpa XP_002299788 323 35737 G188 S L G E S N N G H S S T V W A
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565615 352 39113 H212 L G E S N N G H S S T V W S I
Baker's Yeast Sacchar. cerevisiae Q05583 330 37256 G195 E C V A V L N G H E G T V W S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 71.8 99.7 97.3 N.A. 94.9 94.4 N.A. 50.1 51.6 N.A. 76.1 N.A. 58.1 58.4 38.6 60
Protein Similarity: 100 71.8 99.7 98.8 N.A. 97.9 97.3 N.A. 54.2 57.5 N.A. 85.8 N.A. 72.2 75.5 57.2 75.8
P-Site Identity: 100 100 100 100 N.A. 93.3 93.3 N.A. 6.6 13.3 N.A. 6.6 N.A. 53.3 0 6.6 66.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 13.3 26.6 N.A. 20 N.A. 60 13.3 20 93.3
Percent
Protein Identity: 49.2 N.A. N.A. 48 41.8 N.A.
Protein Similarity: 63.4 N.A. N.A. 64.7 59.8 N.A.
P-Site Identity: 0 N.A. N.A. 20 0 N.A.
P-Site Similarity: 13.3 N.A. N.A. 26.6 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 13 0 0 13 0 0 0 7 0 44 7 0 7 0 7 % A
% Cys: 0 7 0 0 0 7 7 0 0 0 0 7 0 0 0 % C
% Asp: 0 0 7 0 7 0 0 0 7 7 0 50 7 13 7 % D
% Glu: 7 0 50 13 0 0 13 0 0 7 0 0 0 0 0 % E
% Phe: 0 7 0 0 0 0 0 0 0 0 50 0 0 0 7 % F
% Gly: 44 7 7 7 7 13 7 19 0 7 7 0 0 0 50 % G
% His: 0 50 7 0 0 7 0 13 13 0 0 0 0 0 0 % H
% Ile: 0 0 0 7 0 0 0 0 25 0 0 0 0 0 13 % I
% Lys: 0 0 7 0 0 0 0 0 0 7 0 0 7 7 0 % K
% Leu: 7 13 13 0 0 7 0 0 32 7 0 0 7 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 7 0 0 0 7 13 13 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 38 0 0 % P
% Gln: 7 7 0 0 0 0 0 0 0 0 0 0 0 0 7 % Q
% Arg: 0 0 0 0 0 0 0 13 0 0 0 0 0 0 0 % R
% Ser: 19 7 0 57 19 0 7 44 13 19 19 7 7 50 7 % S
% Thr: 0 7 7 7 57 7 0 0 7 0 13 13 0 13 0 % T
% Val: 0 0 7 0 7 50 7 0 7 7 0 19 13 7 0 % V
% Trp: 0 0 0 0 0 0 50 7 0 0 7 7 19 13 7 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _