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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CIAO1 All Species: 16.14
Human Site: S4 Identified Species: 23.68
UniProt: O76071 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O76071 NP_004795.1 339 37840 S4 _ _ _ _ M K D S L V L L G R V
Chimpanzee Pan troglodytes XP_001144741 472 51924 S137 R R A D M K D S L V L L G R V
Rhesus Macaque Macaca mulatta XP_001098395 339 37880 S4 _ _ _ _ M K D S L V L L G R V
Dog Lupus familis XP_532950 339 37846 S4 _ _ _ _ M K D S L V L L G R V
Cat Felis silvestris
Mouse Mus musculus Q99KN2 339 37614 S4 _ _ _ _ M K D S L V L Q S R V
Rat Rattus norvegicus Q5M7T1 339 37599 A4 _ _ _ _ M K D A L V L Q S R V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517379 223 24600
Chicken Gallus gallus XP_423992 209 23301
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q6P0D9 330 36784
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7K1Y4 335 37026 L4 _ _ _ _ M G R L I L E H T L Q
Honey Bee Apis mellifera XP_395314 332 37365
Nematode Worm Caenorhab. elegans Q9XW12 337 38172 I5 _ _ _ M L R Q I G E F Y H Q G
Sea Urchin Strong. purpuratus XP_781960 340 38037 K4 _ _ _ _ M D G K L Q P I S T L
Poplar Tree Populus trichocarpa XP_002299788 323 35737
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565615 352 39113 E17 L V E I Q K L E G H T D R V W
Baker's Yeast Sacchar. cerevisiae Q05583 330 37256
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 71.8 99.7 97.3 N.A. 94.9 94.4 N.A. 50.1 51.6 N.A. 76.1 N.A. 58.1 58.4 38.6 60
Protein Similarity: 100 71.8 99.7 98.8 N.A. 97.9 97.3 N.A. 54.2 57.5 N.A. 85.8 N.A. 72.2 75.5 57.2 75.8
P-Site Identity: 100 73.3 100 100 N.A. 81.8 72.7 N.A. 0 0 N.A. 0 N.A. 9 0 0 18.1
P-Site Similarity: 100 73.3 100 100 N.A. 81.8 81.8 N.A. 0 0 N.A. 0 N.A. 27.2 0 25 36.3
Percent
Protein Identity: 49.2 N.A. N.A. 48 41.8 N.A.
Protein Similarity: 63.4 N.A. N.A. 64.7 59.8 N.A.
P-Site Identity: 0 N.A. N.A. 6.6 0 N.A.
P-Site Similarity: 0 N.A. N.A. 13.3 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 0 0 0 0 7 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 7 0 7 38 0 0 0 0 7 0 0 0 % D
% Glu: 0 0 7 0 0 0 0 7 0 7 7 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % F
% Gly: 0 0 0 0 0 7 7 0 13 0 0 0 25 0 7 % G
% His: 0 0 0 0 0 0 0 0 0 7 0 7 7 0 0 % H
% Ile: 0 0 0 7 0 0 0 7 7 0 0 7 0 0 0 % I
% Lys: 0 0 0 0 0 44 0 7 0 0 0 0 0 0 0 % K
% Leu: 7 0 0 0 7 0 7 7 44 7 38 25 0 7 7 % L
% Met: 0 0 0 7 50 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % P
% Gln: 0 0 0 0 7 0 7 0 0 7 0 13 0 7 7 % Q
% Arg: 7 7 0 0 0 7 7 0 0 0 0 0 7 38 0 % R
% Ser: 0 0 0 0 0 0 0 32 0 0 0 0 19 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 7 0 7 7 0 % T
% Val: 0 7 0 0 0 0 0 0 0 38 0 0 0 7 38 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % Y
% Spaces: 50 50 50 44 0 0 0 0 0 0 0 0 0 0 0 % _