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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDE5A All Species: 11.52
Human Site: S211 Identified Species: 19.49
UniProt: O76074 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.31
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O76074 NP_001074.2 875 100013 S211 L F D V A E G S T L E E V S N
Chimpanzee Pan troglodytes XP_001150967 875 99910 S211 L F D V A E G S T L E E A S N
Rhesus Macaque Macaca mulatta XP_001099652 875 100002 S211 L F D V A E G S T L E E A S N
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q8CG03 865 98403 L213 A S N N C I R L E W N K G I V
Rat Rattus norvegicus O54735 833 94538 A211 Y E D P R F N A E V D Q I T G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512580 863 98139 E213 S N N C I R L E W N K G I V G
Chicken Gallus gallus P52731 862 99990 E204 L N K L N A S E F S K E D E E
Frog Xenopus laevis NP_001088271 859 97399 E205 S N N C I R L E W K K G I V G
Zebra Danio Brachydanio rerio XP_001923466 856 97075 E209 S N S G I R L E W N K G I V G
Tiger Blowfish Takifugu rubipres Q1KKS3 903 102001 T222 F D V H A G T T V L P S M N S
Fruit Fly Dros. melanogaster Q9VJ79 1451 160911 V466 L V S K L F D V C P R S T V E
Honey Bee Apis mellifera XP_394107 1016 115998 E246 F D V T Q D T E L E E A I Q K
Nematode Worm Caenorhab. elegans P91119 710 81117 T140 I V N A G N Q T I A E I H F Y
Sea Urchin Strong. purpuratus NP_001029121 949 108476 K218 I K N A Y E D K R F N P E V D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 99 N.A. N.A. 92.4 88.9 N.A. 87.8 25.1 75.1 71.1 38.1 31.2 37.5 26.6 39
Protein Similarity: 100 99.7 99.4 N.A. N.A. 94.5 91 N.A. 91.6 44.2 85 83.1 58.1 41.3 54.6 44.2 55.9
P-Site Identity: 100 93.3 93.3 N.A. N.A. 0 6.6 N.A. 0 13.3 0 0 13.3 6.6 6.6 6.6 6.6
P-Site Similarity: 100 93.3 93.3 N.A. N.A. 13.3 46.6 N.A. 20 26.6 20 13.3 40 6.6 20 26.6 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 15 29 8 0 8 0 8 0 8 15 0 0 % A
% Cys: 0 0 0 15 8 0 0 0 8 0 0 0 0 0 0 % C
% Asp: 0 15 29 0 0 8 15 0 0 0 8 0 8 0 8 % D
% Glu: 0 8 0 0 0 29 0 36 15 8 36 29 8 8 15 % E
% Phe: 15 22 0 0 0 15 0 0 8 8 0 0 0 8 0 % F
% Gly: 0 0 0 8 8 8 22 0 0 0 0 22 8 0 29 % G
% His: 0 0 0 8 0 0 0 0 0 0 0 0 8 0 0 % H
% Ile: 15 0 0 0 22 8 0 0 8 0 0 8 36 8 0 % I
% Lys: 0 8 8 8 0 0 0 8 0 8 29 8 0 0 8 % K
% Leu: 36 0 0 8 8 0 22 8 8 29 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % M
% Asn: 0 29 36 8 8 8 8 0 0 15 15 0 0 8 22 % N
% Pro: 0 0 0 8 0 0 0 0 0 8 8 8 0 0 0 % P
% Gln: 0 0 0 0 8 0 8 0 0 0 0 8 0 8 0 % Q
% Arg: 0 0 0 0 8 22 8 0 8 0 8 0 0 0 0 % R
% Ser: 22 8 15 0 0 0 8 22 0 8 0 15 0 22 8 % S
% Thr: 0 0 0 8 0 0 15 15 22 0 0 0 8 8 0 % T
% Val: 0 15 15 22 0 0 0 8 8 8 0 0 8 36 8 % V
% Trp: 0 0 0 0 0 0 0 0 22 8 0 0 0 0 0 % W
% Tyr: 8 0 0 0 8 0 0 0 0 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _