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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDE5A All Species: 12.12
Human Site: S29 Identified Species: 20.51
UniProt: O76074 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O76074 NP_001074.2 875 100013 S29 Q Q Q R D Q D S V E A W L D D
Chimpanzee Pan troglodytes XP_001150967 875 99910 S29 Q Q Q R D Q D S V E A W L D D
Rhesus Macaque Macaca mulatta XP_001099652 875 100002 S29 Q Q Q R D Q D S V E A W L D D
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q8CG03 865 98403 T31 L D D H R D F T F S Y F I R K
Rat Rattus norvegicus O54735 833 94538 G29 N I P V C K E G I R A H T E S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512580 863 98139 S31 L F S P Y Y P S L P F S N K S
Chicken Gallus gallus P52731 862 99990 E22 N N P Q F A K E Y F D R K M R
Frog Xenopus laevis NP_001088271 859 97399 H23 A E S W T A T H S T T G G N V
Zebra Danio Brachydanio rerio XP_001923466 856 97075 F27 L E F A H S Y F V R K A S R E
Tiger Blowfish Takifugu rubipres Q1KKS3 903 102001 K40 S M V E K W L K N H Q A G K S
Fruit Fly Dros. melanogaster Q9VJ79 1451 160911 T284 L L K P I V N T I D G T P T F
Honey Bee Apis mellifera XP_394107 1016 115998 K64 I V K L C R S K R I T C Q D T
Nematode Worm Caenorhab. elegans P91119 710 81117
Sea Urchin Strong. purpuratus NP_001029121 949 108476 M36 V T K A T P D M I D Q W L S K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 99 N.A. N.A. 92.4 88.9 N.A. 87.8 25.1 75.1 71.1 38.1 31.2 37.5 26.6 39
Protein Similarity: 100 99.7 99.4 N.A. N.A. 94.5 91 N.A. 91.6 44.2 85 83.1 58.1 41.3 54.6 44.2 55.9
P-Site Identity: 100 100 100 N.A. N.A. 0 6.6 N.A. 6.6 0 0 6.6 0 0 6.6 0 20
P-Site Similarity: 100 100 100 N.A. N.A. 20 33.3 N.A. 13.3 6.6 13.3 20 0 33.3 20 0 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 15 0 15 0 0 0 0 29 15 0 0 0 % A
% Cys: 0 0 0 0 15 0 0 0 0 0 0 8 0 0 0 % C
% Asp: 0 8 8 0 22 8 29 0 0 15 8 0 0 29 22 % D
% Glu: 0 15 0 8 0 0 8 8 0 22 0 0 0 8 8 % E
% Phe: 0 8 8 0 8 0 8 8 8 8 8 8 0 0 8 % F
% Gly: 0 0 0 0 0 0 0 8 0 0 8 8 15 0 0 % G
% His: 0 0 0 8 8 0 0 8 0 8 0 8 0 0 0 % H
% Ile: 8 8 0 0 8 0 0 0 22 8 0 0 8 0 0 % I
% Lys: 0 0 22 0 8 8 8 15 0 0 8 0 8 15 15 % K
% Leu: 29 8 0 8 0 0 8 0 8 0 0 0 29 0 0 % L
% Met: 0 8 0 0 0 0 0 8 0 0 0 0 0 8 0 % M
% Asn: 15 8 0 0 0 0 8 0 8 0 0 0 8 8 0 % N
% Pro: 0 0 15 15 0 8 8 0 0 8 0 0 8 0 0 % P
% Gln: 22 22 22 8 0 22 0 0 0 0 15 0 8 0 0 % Q
% Arg: 0 0 0 22 8 8 0 0 8 15 0 8 0 15 8 % R
% Ser: 8 0 15 0 0 8 8 29 8 8 0 8 8 8 22 % S
% Thr: 0 8 0 0 15 0 8 15 0 8 15 8 8 8 8 % T
% Val: 8 8 8 8 0 8 0 0 29 0 0 0 0 0 8 % V
% Trp: 0 0 0 8 0 8 0 0 0 0 0 29 0 0 0 % W
% Tyr: 0 0 0 0 8 8 8 0 8 0 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _