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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE5A
All Species:
36.67
Human Site:
S346
Identified Species:
62.05
UniProt:
O76074
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76074
NP_001074.2
875
100013
S346
L
I
F
E
E
Q
Q
S
L
E
V
I
L
K
K
Chimpanzee
Pan troglodytes
XP_001150967
875
99910
S346
L
I
F
E
E
Q
Q
S
L
E
V
I
L
K
K
Rhesus Macaque
Macaca mulatta
XP_001099652
875
100002
S346
L
I
F
E
E
Q
Q
S
L
E
V
I
L
K
K
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG03
865
98403
S336
L
I
F
E
E
Q
Q
S
L
E
V
I
L
K
K
Rat
Rattus norvegicus
O54735
833
94538
T326
F
M
Q
V
Q
K
C
T
I
F
I
V
D
E
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512580
863
98139
S335
L
I
F
E
E
Q
Q
S
L
E
V
I
L
K
K
Chicken
Gallus gallus
P52731
862
99990
F317
P
D
G
R
E
V
N
F
Y
K
I
I
D
Y
I
Frog
Xenopus laevis
NP_001088271
859
97399
S327
L
I
F
E
E
Q
Q
S
L
E
V
I
L
K
K
Zebra Danio
Brachydanio rerio
XP_001923466
856
97075
S331
L
I
F
E
E
Q
Q
S
L
E
V
L
L
R
K
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
D356
D
L
F
E
E
Q
T
D
L
E
K
I
V
R
K
Fruit Fly
Dros. melanogaster
Q9VJ79
1451
160911
T604
M
I
F
E
E
Q
S
T
I
E
H
M
V
F
R
Honey Bee
Apis mellifera
XP_394107
1016
115998
N383
N
I
F
E
E
Q
N
N
L
E
C
L
V
T
K
Nematode Worm
Caenorhab. elegans
P91119
710
81117
A252
F
A
Q
K
L
V
D
A
D
R
A
S
L
F
L
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
S333
G
I
F
E
E
Q
T
S
L
D
N
V
V
H
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99
N.A.
N.A.
92.4
88.9
N.A.
87.8
25.1
75.1
71.1
38.1
31.2
37.5
26.6
39
Protein Similarity:
100
99.7
99.4
N.A.
N.A.
94.5
91
N.A.
91.6
44.2
85
83.1
58.1
41.3
54.6
44.2
55.9
P-Site Identity:
100
100
100
N.A.
N.A.
100
0
N.A.
100
13.3
100
86.6
53.3
40
53.3
6.6
53.3
P-Site Similarity:
100
100
100
N.A.
N.A.
100
53.3
N.A.
100
26.6
100
100
73.3
80
73.3
20
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
0
8
0
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
8
0
0
0
0
% C
% Asp:
8
8
0
0
0
0
8
8
8
8
0
0
15
0
8
% D
% Glu:
0
0
0
79
86
0
0
0
0
72
0
0
0
8
0
% E
% Phe:
15
0
79
0
0
0
0
8
0
8
0
0
0
15
0
% F
% Gly:
8
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
0
% H
% Ile:
0
72
0
0
0
0
0
0
15
0
15
58
0
0
8
% I
% Lys:
0
0
0
8
0
8
0
0
0
8
8
0
0
43
72
% K
% Leu:
50
8
0
0
8
0
0
0
72
0
0
15
58
0
8
% L
% Met:
8
8
0
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
8
0
0
0
0
0
15
8
0
0
8
0
0
0
0
% N
% Pro:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
15
0
8
79
50
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
8
0
0
0
0
0
8
0
0
0
15
8
% R
% Ser:
0
0
0
0
0
0
8
58
0
0
0
8
0
0
0
% S
% Thr:
0
0
0
0
0
0
15
15
0
0
0
0
0
8
0
% T
% Val:
0
0
0
8
0
15
0
0
0
0
50
15
29
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _