KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE5A
All Species:
29.39
Human Site:
S379
Identified Species:
49.74
UniProt:
O76074
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76074
NP_001074.2
875
100013
S379
V
D
E
D
C
S
D
S
F
S
S
V
F
H
M
Chimpanzee
Pan troglodytes
XP_001150967
875
99910
S379
V
D
E
D
C
S
D
S
F
S
S
V
F
H
M
Rhesus Macaque
Macaca mulatta
XP_001099652
875
100002
S379
V
D
E
D
C
S
D
S
F
S
S
V
F
H
M
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG03
865
98403
S369
V
D
E
D
C
P
D
S
F
S
R
V
F
H
M
Rat
Rattus norvegicus
O54735
833
94538
E359
S
S
E
P
L
T
R
E
H
D
A
N
K
I
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512580
863
98139
S368
V
D
E
D
C
S
D
S
F
S
S
V
F
H
M
Chicken
Gallus gallus
P52731
862
99990
T350
C
L
I
S
G
L
P
T
Y
V
A
E
N
G
F
Frog
Xenopus laevis
NP_001088271
859
97399
T360
V
D
E
D
S
P
D
T
F
S
S
V
F
H
M
Zebra Danio
Brachydanio rerio
XP_001923466
856
97075
T364
S
D
R
E
T
A
N
T
F
A
S
V
F
H
M
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
V389
L
E
D
I
E
S
P
V
V
K
F
T
K
S
F
Fruit Fly
Dros. melanogaster
Q9VJ79
1451
160911
S637
V
H
E
A
D
K
G
S
F
S
R
V
F
D
F
Honey Bee
Apis mellifera
XP_394107
1016
115998
A416
L
D
L
D
C
G
E
A
G
H
L
E
K
I
V
Nematode Worm
Caenorhab. elegans
P91119
710
81117
N285
D
E
E
H
V
R
V
N
S
E
G
Q
K
E
I
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
Y366
L
E
T
T
E
E
S
Y
L
P
A
Q
L
R
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99
N.A.
N.A.
92.4
88.9
N.A.
87.8
25.1
75.1
71.1
38.1
31.2
37.5
26.6
39
Protein Similarity:
100
99.7
99.4
N.A.
N.A.
94.5
91
N.A.
91.6
44.2
85
83.1
58.1
41.3
54.6
44.2
55.9
P-Site Identity:
100
100
100
N.A.
N.A.
86.6
6.6
N.A.
100
0
80
46.6
6.6
46.6
20
6.6
6.6
P-Site Similarity:
100
100
100
N.A.
N.A.
86.6
20
N.A.
100
20
86.6
80
26.6
46.6
46.6
26.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
8
0
8
0
8
22
0
0
0
0
% A
% Cys:
8
0
0
0
43
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
58
8
50
8
0
43
0
0
8
0
0
0
8
0
% D
% Glu:
0
22
65
8
15
8
8
8
0
8
0
15
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
58
0
8
0
58
0
22
% F
% Gly:
0
0
0
0
8
8
8
0
8
0
8
0
0
8
0
% G
% His:
0
8
0
8
0
0
0
0
8
8
0
0
0
50
0
% H
% Ile:
0
0
8
8
0
0
0
0
0
0
0
0
0
15
8
% I
% Lys:
0
0
0
0
0
8
0
0
0
8
0
0
29
0
0
% K
% Leu:
22
8
8
0
8
8
0
0
8
0
8
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
58
% M
% Asn:
0
0
0
0
0
0
8
8
0
0
0
8
8
0
8
% N
% Pro:
0
0
0
8
0
15
15
0
0
8
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
15
0
0
0
% Q
% Arg:
0
0
8
0
0
8
8
0
0
0
15
0
0
8
0
% R
% Ser:
15
8
0
8
8
36
8
43
8
50
43
0
0
8
0
% S
% Thr:
0
0
8
8
8
8
0
22
0
0
0
8
0
0
0
% T
% Val:
50
0
0
0
8
0
8
8
8
8
0
58
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
8
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _