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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE5A
All Species:
20.3
Human Site:
S394
Identified Species:
34.36
UniProt:
O76074
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76074
NP_001074.2
875
100013
S394
E
C
E
E
L
E
K
S
S
D
T
L
T
R
E
Chimpanzee
Pan troglodytes
XP_001150967
875
99910
S394
E
C
E
E
L
E
K
S
S
D
T
L
T
R
E
Rhesus Macaque
Macaca mulatta
XP_001099652
875
100002
S394
E
C
E
E
L
E
K
S
S
D
M
L
T
R
E
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG03
865
98403
P384
E
C
E
E
V
G
K
P
S
D
P
L
T
R
E
Rat
Rattus norvegicus
O54735
833
94538
K374
Y
M
Y
A
Q
Y
V
K
N
T
M
E
P
L
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512580
863
98139
S383
K
F
E
E
L
E
D
S
A
D
A
L
K
R
D
Chicken
Gallus gallus
P52731
862
99990
P365
I
C
N
M
M
N
A
P
A
D
E
Y
F
T
F
Frog
Xenopus laevis
NP_001088271
859
97399
S375
E
S
D
E
L
Q
E
S
A
N
A
V
K
R
E
Zebra Danio
Brachydanio rerio
XP_001923466
856
97075
S379
E
Y
E
E
I
A
G
S
T
D
F
P
N
R
E
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
S404
E
L
L
S
P
K
C
S
A
D
A
E
S
S
F
Fruit Fly
Dros. melanogaster
Q9VJ79
1451
160911
E652
E
A
N
D
L
S
E
E
E
A
T
S
R
T
S
Honey Bee
Apis mellifera
XP_394107
1016
115998
Q431
E
R
P
G
K
S
M
Q
E
S
R
K
P
L
S
Nematode Worm
Caenorhab. elegans
P91119
710
81117
I300
R
F
D
M
S
K
G
I
A
G
Y
V
A
S
T
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
I381
A
E
G
K
R
H
S
I
A
Y
Q
S
S
F
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99
N.A.
N.A.
92.4
88.9
N.A.
87.8
25.1
75.1
71.1
38.1
31.2
37.5
26.6
39
Protein Similarity:
100
99.7
99.4
N.A.
N.A.
94.5
91
N.A.
91.6
44.2
85
83.1
58.1
41.3
54.6
44.2
55.9
P-Site Identity:
100
100
93.3
N.A.
N.A.
73.3
0
N.A.
53.3
13.3
40
46.6
20
20
6.6
0
0
P-Site Similarity:
100
100
93.3
N.A.
N.A.
80
6.6
N.A.
73.3
26.6
80
60
40
33.3
6.6
26.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
8
0
8
8
0
43
8
22
0
8
0
0
% A
% Cys:
0
36
0
0
0
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
15
8
0
0
8
0
0
58
0
0
0
0
15
% D
% Glu:
65
8
43
50
0
29
15
8
15
0
8
15
0
0
43
% E
% Phe:
0
15
0
0
0
0
0
0
0
0
8
0
8
8
15
% F
% Gly:
0
0
8
8
0
8
15
0
0
8
0
0
0
0
0
% G
% His:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
8
0
0
15
0
0
0
0
0
0
0
% I
% Lys:
8
0
0
8
8
15
29
8
0
0
0
8
15
0
0
% K
% Leu:
0
8
8
0
43
0
0
0
0
0
0
36
0
15
0
% L
% Met:
0
8
0
15
8
0
8
0
0
0
15
0
0
0
0
% M
% Asn:
0
0
15
0
0
8
0
0
8
8
0
0
8
0
8
% N
% Pro:
0
0
8
0
8
0
0
15
0
0
8
8
15
0
0
% P
% Gln:
0
0
0
0
8
8
0
8
0
0
8
0
0
0
0
% Q
% Arg:
8
8
0
0
8
0
0
0
0
0
8
0
8
50
0
% R
% Ser:
0
8
0
8
8
15
8
50
29
8
0
15
15
15
15
% S
% Thr:
0
0
0
0
0
0
0
0
8
8
22
0
29
15
8
% T
% Val:
0
0
0
0
8
0
8
0
0
0
0
15
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
8
8
0
0
8
0
0
0
8
8
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _