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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE5A
All Species:
18.48
Human Site:
S428
Identified Species:
31.28
UniProt:
O76074
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76074
NP_001074.2
875
100013
S428
P
L
N
I
P
D
V
S
K
D
K
R
F
P
W
Chimpanzee
Pan troglodytes
XP_001150967
875
99910
S428
P
L
N
I
P
D
V
S
K
D
K
R
F
P
W
Rhesus Macaque
Macaca mulatta
XP_001099652
875
100002
S428
P
L
N
I
P
D
V
S
K
D
K
R
F
P
W
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG03
865
98403
T418
P
L
N
I
P
D
V
T
K
D
K
R
F
P
W
Rat
Rattus norvegicus
O54735
833
94538
S408
I
N
T
H
C
I
R
S
L
L
C
T
P
I
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512580
863
98139
C417
P
L
N
I
P
D
V
C
Q
D
R
R
F
P
W
Chicken
Gallus gallus
P52731
862
99990
I399
I
V
N
K
K
E
E
I
V
G
V
A
T
F
Y
Frog
Xenopus laevis
NP_001088271
859
97399
C409
P
I
N
I
P
D
I
C
K
D
T
R
F
P
W
Zebra Danio
Brachydanio rerio
XP_001923466
856
97075
T413
T
L
N
I
T
D
T
T
K
D
Q
L
F
S
W
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
L438
E
L
V
A
S
T
G
L
P
V
N
I
S
D
A
Fruit Fly
Dros. melanogaster
Q9VJ79
1451
160911
N686
G
E
T
V
N
V
P
N
A
Y
E
D
D
R
F
Honey Bee
Apis mellifera
XP_394107
1016
115998
Y465
E
T
Q
K
A
K
V
Y
R
P
S
A
S
D
L
Nematode Worm
Caenorhab. elegans
P91119
710
81117
T334
D
S
K
T
G
Y
T
T
K
T
I
L
C
M
P
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
T415
E
D
T
E
K
L
K
T
I
P
H
E
M
L
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99
N.A.
N.A.
92.4
88.9
N.A.
87.8
25.1
75.1
71.1
38.1
31.2
37.5
26.6
39
Protein Similarity:
100
99.7
99.4
N.A.
N.A.
94.5
91
N.A.
91.6
44.2
85
83.1
58.1
41.3
54.6
44.2
55.9
P-Site Identity:
100
100
100
N.A.
N.A.
93.3
6.6
N.A.
80
6.6
73.3
53.3
6.6
0
6.6
6.6
0
P-Site Similarity:
100
100
100
N.A.
N.A.
100
6.6
N.A.
93.3
26.6
86.6
66.6
6.6
26.6
13.3
13.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
8
0
0
0
8
0
0
15
0
0
8
% A
% Cys:
0
0
0
0
8
0
0
15
0
0
8
0
8
0
0
% C
% Asp:
8
8
0
0
0
50
0
0
0
50
0
8
8
15
0
% D
% Glu:
22
8
0
8
0
8
8
0
0
0
8
8
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
50
8
8
% F
% Gly:
8
0
0
0
8
0
8
0
0
8
0
0
0
0
0
% G
% His:
0
0
0
8
0
0
0
0
0
0
8
0
0
0
0
% H
% Ile:
15
8
0
50
0
8
8
8
8
0
8
8
0
8
0
% I
% Lys:
0
0
8
15
15
8
8
0
50
0
29
0
0
0
15
% K
% Leu:
0
50
0
0
0
8
0
8
8
8
0
15
0
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
0
% M
% Asn:
0
8
58
0
8
0
0
8
0
0
8
0
0
0
0
% N
% Pro:
43
0
0
0
43
0
8
0
8
15
0
0
8
43
8
% P
% Gln:
0
0
8
0
0
0
0
0
8
0
8
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
8
0
8
0
8
43
0
8
0
% R
% Ser:
0
8
0
0
8
0
0
29
0
0
8
0
15
8
0
% S
% Thr:
8
8
22
8
8
8
15
29
0
8
8
8
8
0
0
% T
% Val:
0
8
8
8
0
8
43
0
8
8
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
50
% W
% Tyr:
0
0
0
0
0
8
0
8
0
8
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _