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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE5A
All Species:
40
Human Site:
S562
Identified Species:
67.69
UniProt:
O76074
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76074
NP_001074.2
875
100013
S562
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
Chimpanzee
Pan troglodytes
XP_001150967
875
99910
S562
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
Rhesus Macaque
Macaca mulatta
XP_001099652
875
100002
S562
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG03
865
98403
S552
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
Rat
Rattus norvegicus
O54735
833
94538
S520
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512580
863
98139
S550
K
L
I
D
F
S
F
S
D
F
E
L
S
D
L
Chicken
Gallus gallus
P52731
862
99990
S512
E
L
Y
E
F
R
F
S
D
F
P
V
T
E
H
Frog
Xenopus laevis
NP_001088271
859
97399
S542
K
L
T
E
F
Y
F
S
D
F
E
L
S
D
M
Zebra Danio
Brachydanio rerio
XP_001923466
856
97075
S548
R
L
M
D
Y
S
F
S
D
F
D
L
T
D
A
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
S571
K
L
S
F
D
D
F
S
L
D
V
D
A
M
I
Fruit Fly
Dros. melanogaster
Q9VJ79
1451
160911
H813
D
F
K
F
D
D
I
H
F
E
D
D
D
T
L
Honey Bee
Apis mellifera
XP_394107
1016
115998
D619
S
F
T
F
I
D
F
D
L
T
D
E
D
T
C
Nematode Worm
Caenorhab. elegans
P91119
710
81117
P446
R
L
S
E
L
E
K
P
L
Y
A
V
Y
M
F
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
S568
K
L
Y
E
F
S
F
S
D
F
D
L
T
E
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99
N.A.
N.A.
92.4
88.9
N.A.
87.8
25.1
75.1
71.1
38.1
31.2
37.5
26.6
39
Protein Similarity:
100
99.7
99.4
N.A.
N.A.
94.5
91
N.A.
91.6
44.2
85
83.1
58.1
41.3
54.6
44.2
55.9
P-Site Identity:
100
100
100
N.A.
N.A.
100
100
N.A.
86.6
33.3
73.3
53.3
20
6.6
13.3
0
53.3
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
93.3
73.3
93.3
86.6
46.6
13.3
20
40
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
8
0
8
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
8
0
0
50
15
22
0
8
72
8
29
15
15
58
8
% D
% Glu:
8
0
0
29
0
8
0
0
0
8
50
8
0
15
0
% E
% Phe:
0
15
0
22
65
0
86
0
8
72
0
0
0
0
8
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
8
% H
% Ile:
0
36
8
0
8
0
8
0
0
0
0
0
0
0
8
% I
% Lys:
65
0
8
0
0
0
8
0
0
0
0
0
0
0
0
% K
% Leu:
0
50
0
0
8
0
0
0
22
0
0
65
0
0
50
% L
% Met:
0
0
8
0
0
0
0
0
0
0
0
0
0
15
8
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
8
0
0
8
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
15
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% R
% Ser:
8
0
15
0
0
58
0
79
0
0
0
0
50
0
0
% S
% Thr:
0
0
50
0
0
0
0
0
0
8
0
0
22
15
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
8
15
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
15
0
8
8
0
0
0
8
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _