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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDE5A All Species: 37.88
Human Site: S663 Identified Species: 64.1
UniProt: O76074 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O76074 NP_001074.2 875 100013 S663 D H R G V N N S Y I Q R S E H
Chimpanzee Pan troglodytes XP_001150967 875 99910 S663 D H R G V N N S Y I Q R S E H
Rhesus Macaque Macaca mulatta XP_001099652 875 100002 S663 D H R G V N N S Y I Q R S E H
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q8CG03 865 98403 S653 D H R G V N N S Y I Q R S E H
Rat Rattus norvegicus O54735 833 94538 S621 D H R G V N N S Y I Q R S E H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512580 863 98139 S651 D H R G V N N S Y I Q R S D H
Chicken Gallus gallus P52731 862 99990 L612 D H R G T N N L Y Q M K S A A
Frog Xenopus laevis NP_001088271 859 97399 S643 D H R G V N N S F I Q R S E H
Zebra Danio Brachydanio rerio XP_001923466 856 97075 S649 D H R G V N N S Y I K R S D H
Tiger Blowfish Takifugu rubipres Q1KKS3 903 102001 A668 D H R G T N N A F Q A K T G S
Fruit Fly Dros. melanogaster Q9VJ79 1451 160911 S910 D H R G T N N S F Q I K A S S
Honey Bee Apis mellifera XP_394107 1016 115998 A716 D H R G T N N A F Q M K T E S
Nematode Worm Caenorhab. elegans P91119 710 81117 M538 N N A Y M K T M S T P L A S I
Sea Urchin Strong. purpuratus NP_001029121 949 108476 T668 D H R G T N N T F Q V K T S S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 99 N.A. N.A. 92.4 88.9 N.A. 87.8 25.1 75.1 71.1 38.1 31.2 37.5 26.6 39
Protein Similarity: 100 99.7 99.4 N.A. N.A. 94.5 91 N.A. 91.6 44.2 85 83.1 58.1 41.3 54.6 44.2 55.9
P-Site Identity: 100 100 100 N.A. N.A. 100 100 N.A. 93.3 53.3 93.3 86.6 40 46.6 46.6 0 40
P-Site Similarity: 100 100 100 N.A. N.A. 100 100 N.A. 100 60 100 100 66.6 66.6 73.3 26.6 66.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 0 0 0 15 0 0 8 0 15 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 93 0 0 0 0 0 0 0 0 0 0 0 0 15 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 50 0 % E
% Phe: 0 0 0 0 0 0 0 0 36 0 0 0 0 0 0 % F
% Gly: 0 0 0 93 0 0 0 0 0 0 0 0 0 8 0 % G
% His: 0 93 0 0 0 0 0 0 0 0 0 0 0 0 58 % H
% Ile: 0 0 0 0 0 0 0 0 0 58 8 0 0 0 8 % I
% Lys: 0 0 0 0 0 8 0 0 0 0 8 36 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 8 0 0 0 8 0 0 0 % L
% Met: 0 0 0 0 8 0 0 8 0 0 15 0 0 0 0 % M
% Asn: 8 8 0 0 0 93 93 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 36 50 0 0 0 0 % Q
% Arg: 0 0 93 0 0 0 0 0 0 0 0 58 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 65 8 0 0 0 65 22 29 % S
% Thr: 0 0 0 0 36 0 8 8 0 8 0 0 22 0 0 % T
% Val: 0 0 0 0 58 0 0 0 0 0 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 0 0 0 0 58 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _