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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDE5A All Species: 40.3
Human Site: T263 Identified Species: 68.21
UniProt: O76074 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O76074 NP_001074.2 875 100013 T263 D Q I T G Y K T Q S I L C M P
Chimpanzee Pan troglodytes XP_001150967 875 99910 T263 D Q I T G Y K T Q S I L C M P
Rhesus Macaque Macaca mulatta XP_001099652 875 100002 T263 D Q I T G Y K T Q S I L C M P
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q8CG03 865 98403 T253 D Q I T G Y K T Q S I L C M P
Rat Rattus norvegicus O54735 833 94538 G250 I N K K S G N G G T F T E K D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512580 863 98139 T252 D Q I T G Y K T Q S I L C M P
Chicken Gallus gallus P52731 862 99990 L243 E S R R S Q M L L W S A N K V
Frog Xenopus laevis NP_001088271 859 97399 T244 D Q I T G Y K T Q S I L C M P
Zebra Danio Brachydanio rerio XP_001923466 856 97075 T248 D Q I T G Y K T Q S I L C L P
Tiger Blowfish Takifugu rubipres Q1KKS3 903 102001 T274 D K L T G Y K T K S L L C M P
Fruit Fly Dros. melanogaster Q9VJ79 1451 160911 T523 D S L T G Y R T K A L L C M P
Honey Bee Apis mellifera XP_394107 1016 115998 T301 D M R T G Y K T T L I L S M P
Nematode Worm Caenorhab. elegans P91119 710 81117 Q178 Y S E V R K L Q K H I T C S F
Sea Urchin Strong. purpuratus NP_001029121 949 108476 T258 A Q V I N K I T G S H E F A A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 99 N.A. N.A. 92.4 88.9 N.A. 87.8 25.1 75.1 71.1 38.1 31.2 37.5 26.6 39
Protein Similarity: 100 99.7 99.4 N.A. N.A. 94.5 91 N.A. 91.6 44.2 85 83.1 58.1 41.3 54.6 44.2 55.9
P-Site Identity: 100 100 100 N.A. N.A. 100 0 N.A. 100 0 100 93.3 73.3 60 66.6 13.3 20
P-Site Similarity: 100 100 100 N.A. N.A. 100 6.6 N.A. 100 6.6 100 100 100 93.3 66.6 20 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 0 0 0 0 0 8 0 8 0 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 72 0 0 % C
% Asp: 72 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % D
% Glu: 8 0 8 0 0 0 0 0 0 0 0 8 8 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 8 0 8 0 8 % F
% Gly: 0 0 0 0 72 8 0 8 15 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 8 8 0 0 0 0 % H
% Ile: 8 0 50 8 0 0 8 0 0 0 65 0 0 0 0 % I
% Lys: 0 8 8 8 0 15 65 0 22 0 0 0 0 15 0 % K
% Leu: 0 0 15 0 0 0 8 8 8 8 15 72 0 8 0 % L
% Met: 0 8 0 0 0 0 8 0 0 0 0 0 0 65 0 % M
% Asn: 0 8 0 0 8 0 8 0 0 0 0 0 8 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 72 % P
% Gln: 0 58 0 0 0 8 0 8 50 0 0 0 0 0 0 % Q
% Arg: 0 0 15 8 8 0 8 0 0 0 0 0 0 0 0 % R
% Ser: 0 22 0 0 15 0 0 0 0 65 8 0 8 8 0 % S
% Thr: 0 0 0 72 0 0 0 79 8 8 0 15 0 0 0 % T
% Val: 0 0 8 8 0 0 0 0 0 0 0 0 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 72 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _