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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE5A
All Species:
36.36
Human Site:
T296
Identified Species:
61.54
UniProt:
O76074
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76074
NP_001074.2
875
100013
T296
S
G
N
G
G
T
F
T
E
K
D
E
K
D
F
Chimpanzee
Pan troglodytes
XP_001150967
875
99910
T296
S
G
N
G
G
T
F
T
E
K
D
E
K
D
F
Rhesus Macaque
Macaca mulatta
XP_001099652
875
100002
T296
S
G
N
G
G
T
F
T
E
K
D
E
K
D
F
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG03
865
98403
T286
S
G
N
G
G
T
F
T
E
K
D
E
K
D
F
Rat
Rattus norvegicus
O54735
833
94538
Q276
G
I
V
L
H
N
A
Q
L
Y
E
T
S
L
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512580
863
98139
T285
S
G
N
G
G
T
F
T
E
K
D
E
K
D
F
Chicken
Gallus gallus
P52731
862
99990
T267
Q
F
H
K
A
L
Y
T
I
R
M
Y
L
N
C
Frog
Xenopus laevis
NP_001088271
859
97399
T277
S
G
S
N
G
T
F
T
D
Q
D
E
K
D
F
Zebra Danio
Brachydanio rerio
XP_001923466
856
97075
T281
C
G
E
N
S
T
F
T
E
Q
D
E
K
D
F
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
T306
S
S
S
G
E
L
F
T
E
D
D
E
K
V
L
Fruit Fly
Dros. melanogaster
Q9VJ79
1451
160911
S554
K
M
N
G
E
C
F
S
E
I
D
E
K
V
F
Honey Bee
Apis mellifera
XP_394107
1016
115998
T333
T
N
G
S
N
E
F
T
D
R
D
V
E
V
F
Nematode Worm
Caenorhab. elegans
P91119
710
81117
S202
Y
T
H
K
Q
E
G
S
D
G
Q
D
I
H
E
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
N283
R
I
V
S
H
E
F
N
P
A
D
E
E
V
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99
N.A.
N.A.
92.4
88.9
N.A.
87.8
25.1
75.1
71.1
38.1
31.2
37.5
26.6
39
Protein Similarity:
100
99.7
99.4
N.A.
N.A.
94.5
91
N.A.
91.6
44.2
85
83.1
58.1
41.3
54.6
44.2
55.9
P-Site Identity:
100
100
100
N.A.
N.A.
100
0
N.A.
100
6.6
73.3
66.6
53.3
53.3
26.6
0
26.6
P-Site Similarity:
100
100
100
N.A.
N.A.
100
6.6
N.A.
100
33.3
93.3
73.3
60
60
53.3
26.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
8
0
0
8
0
0
0
0
0
% A
% Cys:
8
0
0
0
0
8
0
0
0
0
0
0
0
0
8
% C
% Asp:
0
0
0
0
0
0
0
0
22
8
79
8
0
50
0
% D
% Glu:
0
0
8
0
15
22
0
0
58
0
8
72
15
0
8
% E
% Phe:
0
8
0
0
0
0
79
0
0
0
0
0
0
0
72
% F
% Gly:
8
50
8
50
43
0
8
0
0
8
0
0
0
0
0
% G
% His:
0
0
15
0
15
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
15
0
0
0
0
0
0
8
8
0
0
8
0
0
% I
% Lys:
8
0
0
15
0
0
0
0
0
36
0
0
65
0
0
% K
% Leu:
0
0
0
8
0
15
0
0
8
0
0
0
8
8
15
% L
% Met:
0
8
0
0
0
0
0
0
0
0
8
0
0
0
0
% M
% Asn:
0
8
43
15
8
8
0
8
0
0
0
0
0
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% P
% Gln:
8
0
0
0
8
0
0
8
0
15
8
0
0
0
0
% Q
% Arg:
8
0
0
0
0
0
0
0
0
15
0
0
0
0
0
% R
% Ser:
50
8
15
15
8
0
0
15
0
0
0
0
8
0
0
% S
% Thr:
8
8
0
0
0
50
0
72
0
0
0
8
0
0
0
% T
% Val:
0
0
15
0
0
0
0
0
0
0
0
8
0
29
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
8
0
0
8
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _