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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE5A
All Species:
23.03
Human Site:
T436
Identified Species:
38.97
UniProt:
O76074
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76074
NP_001074.2
875
100013
T436
K
D
K
R
F
P
W
T
T
E
N
T
G
N
V
Chimpanzee
Pan troglodytes
XP_001150967
875
99910
T436
K
D
K
R
F
P
W
T
T
E
N
T
G
N
V
Rhesus Macaque
Macaca mulatta
XP_001099652
875
100002
T436
K
D
K
R
F
P
W
T
T
E
N
T
G
N
V
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG03
865
98403
T426
K
D
K
R
F
P
W
T
N
E
N
M
G
H
V
Rat
Rattus norvegicus
O54735
833
94538
N416
L
L
C
T
P
I
K
N
G
K
K
N
K
V
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512580
863
98139
T425
Q
D
R
R
F
P
W
T
N
E
N
T
E
N
A
Chicken
Gallus gallus
P52731
862
99990
N407
V
G
V
A
T
F
Y
N
R
K
D
G
K
P
F
Frog
Xenopus laevis
NP_001088271
859
97399
T417
K
D
T
R
F
P
W
T
N
G
N
E
E
K
N
Zebra Danio
Brachydanio rerio
XP_001923466
856
97075
T421
K
D
Q
L
F
S
W
T
V
S
A
Q
G
N
A
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
Y446
P
V
N
I
S
D
A
Y
Q
D
P
R
F
D
A
Fruit Fly
Dros. melanogaster
Q9VJ79
1451
160911
D694
A
Y
E
D
D
R
F
D
A
S
V
D
E
N
S
Honey Bee
Apis mellifera
XP_394107
1016
115998
S473
R
P
S
A
S
D
L
S
N
P
L
S
Q
I
A
Nematode Worm
Caenorhab. elegans
P91119
710
81117
I342
K
T
I
L
C
M
P
I
L
I
R
G
I
V
I
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
N423
I
P
H
E
M
L
K
N
S
I
N
A
T
I
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99
N.A.
N.A.
92.4
88.9
N.A.
87.8
25.1
75.1
71.1
38.1
31.2
37.5
26.6
39
Protein Similarity:
100
99.7
99.4
N.A.
N.A.
94.5
91
N.A.
91.6
44.2
85
83.1
58.1
41.3
54.6
44.2
55.9
P-Site Identity:
100
100
100
N.A.
N.A.
80
0
N.A.
66.6
0
53.3
46.6
0
6.6
0
6.6
6.6
P-Site Similarity:
100
100
100
N.A.
N.A.
86.6
13.3
N.A.
80
20
53.3
53.3
13.3
20
20
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
15
0
0
8
0
8
0
8
8
0
0
36
% A
% Cys:
0
0
8
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
50
0
8
8
15
0
8
0
8
8
8
0
8
0
% D
% Glu:
0
0
8
8
0
0
0
0
0
36
0
8
22
0
0
% E
% Phe:
0
0
0
0
50
8
8
0
0
0
0
0
8
0
8
% F
% Gly:
0
8
0
0
0
0
0
0
8
8
0
15
36
0
0
% G
% His:
0
0
8
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
8
0
8
8
0
8
0
8
0
15
0
0
8
15
15
% I
% Lys:
50
0
29
0
0
0
15
0
0
15
8
0
15
8
0
% K
% Leu:
8
8
0
15
0
8
8
0
8
0
8
0
0
0
0
% L
% Met:
0
0
0
0
8
8
0
0
0
0
0
8
0
0
0
% M
% Asn:
0
0
8
0
0
0
0
22
29
0
50
8
0
43
8
% N
% Pro:
8
15
0
0
8
43
8
0
0
8
8
0
0
8
0
% P
% Gln:
8
0
8
0
0
0
0
0
8
0
0
8
8
0
0
% Q
% Arg:
8
0
8
43
0
8
0
0
8
0
8
8
0
0
0
% R
% Ser:
0
0
8
0
15
8
0
8
8
15
0
8
0
0
8
% S
% Thr:
0
8
8
8
8
0
0
50
22
0
0
29
8
0
0
% T
% Val:
8
8
8
0
0
0
0
0
8
0
8
0
0
15
29
% V
% Trp:
0
0
0
0
0
0
50
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
8
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _