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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDE5A All Species: 11.82
Human Site: T64 Identified Species: 20
UniProt: O76074 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.23
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O76074 NP_001074.2 875 100013 T64 W F A E R V H T I P V C K E G
Chimpanzee Pan troglodytes XP_001150967 875 99910 T64 W F A E R V H T I P V C K E G
Rhesus Macaque Macaca mulatta XP_001099652 875 100002 T64 W F A E R V H T I P V C K E G
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q8CG03 865 98403 T66 K E G I R A H T E S C S C S L
Rat Rattus norvegicus O54735 833 94538 F64 R K I S A S E F D R P L R P I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512580 863 98139 E66 E G V R G H P E S S S C P T Q
Chicken Gallus gallus P52731 862 99990 E57 F K D M S R L E E C N I L F E
Frog Xenopus laevis NP_001088271 859 97399 G58 I P A S K E Q G K N N S E S N
Zebra Danio Brachydanio rerio XP_001923466 856 97075 T62 K A V P E P V T A V H S L G P
Tiger Blowfish Takifugu rubipres Q1KKS3 903 102001 S75 D G L Q R R A S Q K E L R K T
Fruit Fly Dros. melanogaster Q9VJ79 1451 160911 G319 N V G G V V A G Q Y Q Y N H Q
Honey Bee Apis mellifera XP_394107 1016 115998 A99 A H P D A A E A W F R E N A S
Nematode Worm Caenorhab. elegans P91119 710 81117
Sea Urchin Strong. purpuratus NP_001029121 949 108476 E71 D V S M K L T E K G V F Q S I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 99 N.A. N.A. 92.4 88.9 N.A. 87.8 25.1 75.1 71.1 38.1 31.2 37.5 26.6 39
Protein Similarity: 100 99.7 99.4 N.A. N.A. 94.5 91 N.A. 91.6 44.2 85 83.1 58.1 41.3 54.6 44.2 55.9
P-Site Identity: 100 100 100 N.A. N.A. 20 0 N.A. 6.6 0 6.6 6.6 6.6 6.6 0 0 6.6
P-Site Similarity: 100 100 100 N.A. N.A. 20 6.6 N.A. 6.6 6.6 20 6.6 33.3 6.6 6.6 0 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 29 0 15 15 15 8 8 0 0 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 8 8 29 8 0 0 % C
% Asp: 15 0 8 8 0 0 0 0 8 0 0 0 0 0 0 % D
% Glu: 8 8 0 22 8 8 15 22 15 0 8 8 8 22 8 % E
% Phe: 8 22 0 0 0 0 0 8 0 8 0 8 0 8 0 % F
% Gly: 0 15 15 8 8 0 0 15 0 8 0 0 0 8 22 % G
% His: 0 8 0 0 0 8 29 0 0 0 8 0 0 8 0 % H
% Ile: 8 0 8 8 0 0 0 0 22 0 0 8 0 0 15 % I
% Lys: 15 15 0 0 15 0 0 0 15 8 0 0 22 8 0 % K
% Leu: 0 0 8 0 0 8 8 0 0 0 0 15 15 0 8 % L
% Met: 0 0 0 15 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 0 0 0 0 0 0 0 0 8 15 0 15 0 8 % N
% Pro: 0 8 8 8 0 8 8 0 0 22 8 0 8 8 8 % P
% Gln: 0 0 0 8 0 0 8 0 15 0 8 0 8 0 15 % Q
% Arg: 8 0 0 8 36 15 0 0 0 8 8 0 15 0 0 % R
% Ser: 0 0 8 15 8 8 0 8 8 15 8 22 0 22 8 % S
% Thr: 0 0 0 0 0 0 8 36 0 0 0 0 0 8 8 % T
% Val: 0 15 15 0 8 29 8 0 0 8 29 0 0 0 0 % V
% Trp: 22 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 8 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _