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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE5A
All Species:
12.73
Human Site:
T76
Identified Species:
21.54
UniProt:
O76074
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76074
NP_001074.2
875
100013
T76
K
E
G
I
R
G
H
T
E
S
C
S
C
P
L
Chimpanzee
Pan troglodytes
XP_001150967
875
99910
T76
K
E
G
I
R
G
H
T
E
S
C
S
C
P
L
Rhesus Macaque
Macaca mulatta
XP_001099652
875
100002
T76
K
E
G
I
R
G
H
T
E
S
C
S
C
P
L
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG03
865
98403
H78
C
S
L
Q
Q
S
P
H
A
D
N
T
T
P
G
Rat
Rattus norvegicus
O54735
833
94538
S76
R
P
I
V
V
K
D
S
E
G
T
V
S
F
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512580
863
98139
S78
P
T
Q
Q
T
P
H
S
E
I
T
A
H
G
T
Chicken
Gallus gallus
P52731
862
99990
I69
L
F
E
L
L
T
E
I
Q
D
E
A
G
S
M
Frog
Xenopus laevis
NP_001088271
859
97399
Y70
E
S
N
P
Q
V
C
Y
S
E
N
T
T
Q
G
Zebra Danio
Brachydanio rerio
XP_001923466
856
97075
P74
L
G
P
T
D
V
V
P
S
S
S
P
A
P
S
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
K87
R
K
T
F
A
R
S
K
A
I
N
V
N
R
T
Fruit Fly
Dros. melanogaster
Q9VJ79
1451
160911
N331
N
H
Q
Q
H
H
H
N
H
A
H
L
H
H
S
Honey Bee
Apis mellifera
XP_394107
1016
115998
Q111
N
A
S
L
E
L
R
Q
R
F
Q
G
M
A
V
Nematode Worm
Caenorhab. elegans
P91119
710
81117
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
N83
Q
S
I
R
K
S
F
N
I
S
G
T
K
S
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99
N.A.
N.A.
92.4
88.9
N.A.
87.8
25.1
75.1
71.1
38.1
31.2
37.5
26.6
39
Protein Similarity:
100
99.7
99.4
N.A.
N.A.
94.5
91
N.A.
91.6
44.2
85
83.1
58.1
41.3
54.6
44.2
55.9
P-Site Identity:
100
100
100
N.A.
N.A.
6.6
13.3
N.A.
13.3
0
0
13.3
0
6.6
0
0
13.3
P-Site Similarity:
100
100
100
N.A.
N.A.
20
33.3
N.A.
26.6
26.6
20
13.3
13.3
13.3
13.3
0
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
8
0
0
0
15
8
0
15
8
8
0
% A
% Cys:
8
0
0
0
0
0
8
0
0
0
22
0
22
0
0
% C
% Asp:
0
0
0
0
8
0
8
0
0
15
0
0
0
0
0
% D
% Glu:
8
22
8
0
8
0
8
0
36
8
8
0
0
0
0
% E
% Phe:
0
8
0
8
0
0
8
0
0
8
0
0
0
8
0
% F
% Gly:
0
8
22
0
0
22
0
0
0
8
8
8
8
8
15
% G
% His:
0
8
0
0
8
8
36
8
8
0
8
0
15
8
0
% H
% Ile:
0
0
15
22
0
0
0
8
8
15
0
0
0
0
0
% I
% Lys:
22
8
0
0
8
8
0
8
0
0
0
0
8
0
0
% K
% Leu:
15
0
8
15
8
8
0
0
0
0
0
8
0
0
36
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% M
% Asn:
15
0
8
0
0
0
0
15
0
0
22
0
8
0
0
% N
% Pro:
8
8
8
8
0
8
8
8
0
0
0
8
0
36
0
% P
% Gln:
8
0
15
22
15
0
0
8
8
0
8
0
0
8
0
% Q
% Arg:
15
0
0
8
22
8
8
0
8
0
0
0
0
8
0
% R
% Ser:
0
22
8
0
0
15
8
15
15
36
8
22
8
15
15
% S
% Thr:
0
8
8
8
8
8
0
22
0
0
15
22
15
0
15
% T
% Val:
0
0
0
8
8
15
8
0
0
0
0
15
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _