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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDE5A All Species: 26.97
Human Site: Y409 Identified Species: 45.64
UniProt: O76074 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O76074 NP_001074.2 875 100013 Y409 H D A N K I N Y M Y A Q Y V K
Chimpanzee Pan troglodytes XP_001150967 875 99910 Y409 H D A N K I N Y M Y A Q Y V K
Rhesus Macaque Macaca mulatta XP_001099652 875 100002 Y409 H D T N K I N Y M Y A Q Y V K
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q8CG03 865 98403 Y399 Q D A N K I N Y M Y A Q Y V K
Rat Rattus norvegicus O54735 833 94538 N389 I P D V T K D N R F P W T N E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512580 863 98139 Y398 Y D T N K I N Y M Y A Q Y V K
Chicken Gallus gallus P52731 862 99990 T380 Q K G P V D E T G W V I K N V
Frog Xenopus laevis NP_001088271 859 97399 Y390 Y D V S K I N Y M Y A Q Y V A
Zebra Danio Brachydanio rerio XP_001923466 856 97075 Y394 C D V N K I N Y M Y A Q Y V K
Tiger Blowfish Takifugu rubipres Q1KKS3 903 102001 S419 K D S M E K S S Y S D W L I N
Fruit Fly Dros. melanogaster Q9VJ79 1451 160911 I667 P Y E S R F P I N I G I T G H
Honey Bee Apis mellifera XP_394107 1016 115998 G446 R R E A T N D G N K F T T I F
Nematode Worm Caenorhab. elegans P91119 710 81117 N315 G E G L N I E N A Y E D E R F
Sea Urchin Strong. purpuratus NP_001029121 949 108476 N396 A P L N D V K N I S F L K G F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 99 N.A. N.A. 92.4 88.9 N.A. 87.8 25.1 75.1 71.1 38.1 31.2 37.5 26.6 39
Protein Similarity: 100 99.7 99.4 N.A. N.A. 94.5 91 N.A. 91.6 44.2 85 83.1 58.1 41.3 54.6 44.2 55.9
P-Site Identity: 100 100 93.3 N.A. N.A. 93.3 0 N.A. 86.6 0 73.3 86.6 6.6 0 0 13.3 6.6
P-Site Similarity: 100 100 93.3 N.A. N.A. 93.3 20 N.A. 93.3 6.6 86.6 86.6 33.3 13.3 13.3 20 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 22 8 0 0 0 0 8 0 50 0 0 0 8 % A
% Cys: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 58 8 0 8 8 15 0 0 0 8 8 0 0 0 % D
% Glu: 0 8 15 0 8 0 15 0 0 0 8 0 8 0 8 % E
% Phe: 0 0 0 0 0 8 0 0 0 8 15 0 0 0 22 % F
% Gly: 8 0 15 0 0 0 0 8 8 0 8 0 0 15 0 % G
% His: 22 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % H
% Ile: 8 0 0 0 0 58 0 8 8 8 0 15 0 15 0 % I
% Lys: 8 8 0 0 50 15 8 0 0 8 0 0 15 0 43 % K
% Leu: 0 0 8 8 0 0 0 0 0 0 0 8 8 0 0 % L
% Met: 0 0 0 8 0 0 0 0 50 0 0 0 0 0 0 % M
% Asn: 0 0 0 50 8 8 50 22 15 0 0 0 0 15 8 % N
% Pro: 8 15 0 8 0 0 8 0 0 0 8 0 0 0 0 % P
% Gln: 15 0 0 0 0 0 0 0 0 0 0 50 0 0 0 % Q
% Arg: 8 8 0 0 8 0 0 0 8 0 0 0 0 8 0 % R
% Ser: 0 0 8 15 0 0 8 8 0 15 0 0 0 0 0 % S
% Thr: 0 0 15 0 15 0 0 8 0 0 0 8 22 0 0 % T
% Val: 0 0 15 8 8 8 0 0 0 0 8 0 0 50 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 8 0 15 0 0 0 % W
% Tyr: 15 8 0 0 0 0 0 50 8 58 0 0 50 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _