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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE5A
All Species:
28.48
Human Site:
Y414
Identified Species:
48.21
UniProt:
O76074
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76074
NP_001074.2
875
100013
Y414
I
N
Y
M
Y
A
Q
Y
V
K
N
T
M
E
P
Chimpanzee
Pan troglodytes
XP_001150967
875
99910
Y414
I
N
Y
M
Y
A
Q
Y
V
K
N
T
M
E
P
Rhesus Macaque
Macaca mulatta
XP_001099652
875
100002
Y414
I
N
Y
M
Y
A
Q
Y
V
K
N
T
M
E
P
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG03
865
98403
Y404
I
N
Y
M
Y
A
Q
Y
V
K
N
T
M
E
P
Rat
Rattus norvegicus
O54735
833
94538
T394
K
D
N
R
F
P
W
T
N
E
N
M
G
H
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512580
863
98139
Y403
I
N
Y
M
Y
A
Q
Y
V
K
N
T
M
E
P
Chicken
Gallus gallus
P52731
862
99990
K385
D
E
T
G
W
V
I
K
N
V
L
S
L
P
I
Frog
Xenopus laevis
NP_001088271
859
97399
Y395
I
N
Y
M
Y
A
Q
Y
V
A
N
T
M
E
P
Zebra Danio
Brachydanio rerio
XP_001923466
856
97075
Y399
I
N
Y
M
Y
A
Q
Y
V
K
N
T
M
E
T
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
L424
K
S
S
Y
S
D
W
L
I
N
N
S
I
A
E
Fruit Fly
Dros. melanogaster
Q9VJ79
1451
160911
T672
F
P
I
N
I
G
I
T
G
H
V
A
T
T
G
Honey Bee
Apis mellifera
XP_394107
1016
115998
T451
N
D
G
N
K
F
T
T
I
F
E
M
D
N
E
Nematode Worm
Caenorhab. elegans
P91119
710
81117
E320
I
E
N
A
Y
E
D
E
R
F
N
A
D
V
D
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
K401
V
K
N
I
S
F
L
K
G
F
E
L
T
D
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99
N.A.
N.A.
92.4
88.9
N.A.
87.8
25.1
75.1
71.1
38.1
31.2
37.5
26.6
39
Protein Similarity:
100
99.7
99.4
N.A.
N.A.
94.5
91
N.A.
91.6
44.2
85
83.1
58.1
41.3
54.6
44.2
55.9
P-Site Identity:
100
100
100
N.A.
N.A.
100
6.6
N.A.
100
0
93.3
93.3
6.6
0
0
20
0
P-Site Similarity:
100
100
100
N.A.
N.A.
100
26.6
N.A.
100
20
93.3
93.3
33.3
0
13.3
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
50
0
0
0
8
0
15
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
15
0
0
0
8
8
0
0
0
0
0
15
8
8
% D
% Glu:
0
15
0
0
0
8
0
8
0
8
15
0
0
50
22
% E
% Phe:
8
0
0
0
8
15
0
0
0
22
0
0
0
0
0
% F
% Gly:
0
0
8
8
0
8
0
0
15
0
0
0
8
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% H
% Ile:
58
0
8
8
8
0
15
0
15
0
0
0
8
0
15
% I
% Lys:
15
8
0
0
8
0
0
15
0
43
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
8
8
0
0
8
8
8
0
0
% L
% Met:
0
0
0
50
0
0
0
0
0
0
0
15
50
0
0
% M
% Asn:
8
50
22
15
0
0
0
0
15
8
72
0
0
8
0
% N
% Pro:
0
8
0
0
0
8
0
0
0
0
0
0
0
8
43
% P
% Gln:
0
0
0
0
0
0
50
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
8
0
0
0
0
8
0
0
0
0
0
0
% R
% Ser:
0
8
8
0
15
0
0
0
0
0
0
15
0
0
0
% S
% Thr:
0
0
8
0
0
0
8
22
0
0
0
50
15
8
8
% T
% Val:
8
0
0
0
0
8
0
0
50
8
8
0
0
8
0
% V
% Trp:
0
0
0
0
8
0
15
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
50
8
58
0
0
50
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _