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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDE5A All Species: 9.39
Human Site: Y44 Identified Species: 15.9
UniProt: O76074 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.23
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O76074 NP_001074.2 875 100013 Y44 H W D F T F S Y F V R K A T R
Chimpanzee Pan troglodytes XP_001150967 875 99910 Y44 H W D F T F S Y F V R K A T R
Rhesus Macaque Macaca mulatta XP_001099652 875 100002 Y44 H W D F T F S Y F V R K A T R
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q8CG03 865 98403 A46 A T R D M V N A W F S E R V H
Rat Rattus norvegicus O54735 833 94538 S44 C S C S L P Q S P H A D N T T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512580 863 98139 W46 R G E M V N A W F A E R V H T
Chicken Gallus gallus P52731 862 99990 F37 A E V L G S I F Q V S P G D V
Frog Xenopus laevis NP_001088271 859 97399 E38 H A G C T L Q E M V N A W F A
Zebra Danio Brachydanio rerio XP_001923466 856 97075 E42 M V N A W F A E R V H S I Q P
Tiger Blowfish Takifugu rubipres Q1KKS3 903 102001 K55 E A E P K E E K S S V C K D S
Fruit Fly Dros. melanogaster Q9VJ79 1451 160911 D299 L S I G P P M D N G S V G G S
Honey Bee Apis mellifera XP_394107 1016 115998 D79 I H E Y D E D D G L T M E K V
Nematode Worm Caenorhab. elegans P91119 710 81117
Sea Urchin Strong. purpuratus NP_001029121 949 108476 H51 H A N S L H K H G E G S P Q D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 99 N.A. N.A. 92.4 88.9 N.A. 87.8 25.1 75.1 71.1 38.1 31.2 37.5 26.6 39
Protein Similarity: 100 99.7 99.4 N.A. N.A. 94.5 91 N.A. 91.6 44.2 85 83.1 58.1 41.3 54.6 44.2 55.9
P-Site Identity: 100 100 100 N.A. N.A. 0 6.6 N.A. 6.6 6.6 20 13.3 0 0 0 0 6.6
P-Site Similarity: 100 100 100 N.A. N.A. 20 6.6 N.A. 33.3 13.3 20 26.6 6.6 0 20 0 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 15 22 0 8 0 0 15 8 0 8 8 8 22 0 8 % A
% Cys: 8 0 8 8 0 0 0 0 0 0 0 8 0 0 0 % C
% Asp: 0 0 22 8 8 0 8 15 0 0 0 8 0 15 8 % D
% Glu: 8 8 22 0 0 15 8 15 0 8 8 8 8 0 0 % E
% Phe: 0 0 0 22 0 29 0 8 29 8 0 0 0 8 0 % F
% Gly: 0 8 8 8 8 0 0 0 15 8 8 0 15 8 0 % G
% His: 36 8 0 0 0 8 0 8 0 8 8 0 0 8 8 % H
% Ile: 8 0 8 0 0 0 8 0 0 0 0 0 8 0 0 % I
% Lys: 0 0 0 0 8 0 8 8 0 0 0 22 8 8 0 % K
% Leu: 8 0 0 8 15 8 0 0 0 8 0 0 0 0 0 % L
% Met: 8 0 0 8 8 0 8 0 8 0 0 8 0 0 0 % M
% Asn: 0 0 15 0 0 8 8 0 8 0 8 0 8 0 0 % N
% Pro: 0 0 0 8 8 15 0 0 8 0 0 8 8 0 8 % P
% Gln: 0 0 0 0 0 0 15 0 8 0 0 0 0 15 0 % Q
% Arg: 8 0 8 0 0 0 0 0 8 0 22 8 8 0 22 % R
% Ser: 0 15 0 15 0 8 22 8 8 8 22 15 0 0 15 % S
% Thr: 0 8 0 0 29 0 0 0 0 0 8 0 0 29 15 % T
% Val: 0 8 8 0 8 8 0 0 0 43 8 8 8 8 15 % V
% Trp: 0 22 0 0 8 0 0 8 8 0 0 0 8 0 0 % W
% Tyr: 0 0 0 8 0 0 0 22 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _