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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDE5A All Species: 42.73
Human Site: Y509 Identified Species: 72.31
UniProt: O76074 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O76074 NP_001074.2 875 100013 Y509 G I Q N T Q M Y E A V E R A M
Chimpanzee Pan troglodytes XP_001150967 875 99910 Y509 G I Q N T Q M Y E A V E R A M
Rhesus Macaque Macaca mulatta XP_001099652 875 100002 Y509 G I Q N T Q M Y E A V E R A M
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q8CG03 865 98403 Y499 G I Q N T Q M Y E A V E R A M
Rat Rattus norvegicus O54735 833 94538 Y467 G I Q N T Q M Y E A V E R A M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512580 863 98139 Y497 G I Q N T Q M Y E A V E R A M
Chicken Gallus gallus P52731 862 99990 Q459 A Q E M L M Y Q T K A T P T E
Frog Xenopus laevis NP_001088271 859 97399 Y489 A I Q N T Q M Y E V V E R A M
Zebra Danio Brachydanio rerio XP_001923466 856 97075 Y495 G I Q N T Q M Y E A V E R A M
Tiger Blowfish Takifugu rubipres Q1KKS3 903 102001 Y518 G I N N T I M Y D Q V K K S W
Fruit Fly Dros. melanogaster Q9VJ79 1451 160911 Y760 G I H N T H M Y E K A I V A M
Honey Bee Apis mellifera XP_394107 1016 115998 Y566 G I H N T Q M Y E S A C K L M
Nematode Worm Caenorhab. elegans P91119 710 81117 S393 L Y D K I R R S E Q K Y R V A
Sea Urchin Strong. purpuratus NP_001029121 949 108476 T515 C G L G I H N T Q M F E N A M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 99 N.A. N.A. 92.4 88.9 N.A. 87.8 25.1 75.1 71.1 38.1 31.2 37.5 26.6 39
Protein Similarity: 100 99.7 99.4 N.A. N.A. 94.5 91 N.A. 91.6 44.2 85 83.1 58.1 41.3 54.6 44.2 55.9
P-Site Identity: 100 100 100 N.A. N.A. 100 100 N.A. 100 0 86.6 100 46.6 60 60 13.3 20
P-Site Similarity: 100 100 100 N.A. N.A. 100 100 N.A. 100 6.6 86.6 100 73.3 60 73.3 20 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 15 0 0 0 0 0 0 0 0 50 22 0 0 72 8 % A
% Cys: 8 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % C
% Asp: 0 0 8 0 0 0 0 0 8 0 0 0 0 0 0 % D
% Glu: 0 0 8 0 0 0 0 0 79 0 0 65 0 0 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % F
% Gly: 72 8 0 8 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 15 0 0 15 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 79 0 0 15 8 0 0 0 0 0 8 0 0 0 % I
% Lys: 0 0 0 8 0 0 0 0 0 15 8 8 15 0 0 % K
% Leu: 8 0 8 0 8 0 0 0 0 0 0 0 0 8 0 % L
% Met: 0 0 0 8 0 8 79 0 0 8 0 0 0 0 79 % M
% Asn: 0 0 8 79 0 0 8 0 0 0 0 0 8 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % P
% Gln: 0 8 58 0 0 65 0 8 8 15 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 8 8 0 0 0 0 0 65 0 0 % R
% Ser: 0 0 0 0 0 0 0 8 0 8 0 0 0 8 0 % S
% Thr: 0 0 0 0 79 0 0 8 8 0 0 8 0 8 0 % T
% Val: 0 0 0 0 0 0 0 0 0 8 65 0 8 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % W
% Tyr: 0 8 0 0 0 0 8 79 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _