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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE5A
All Species:
43.03
Human Site:
Y709
Identified Species:
72.82
UniProt:
O76074
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76074
NP_001074.2
875
100013
Y709
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
Chimpanzee
Pan troglodytes
XP_001150967
875
99910
Y709
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
Rhesus Macaque
Macaca mulatta
XP_001099652
875
100002
Y709
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG03
865
98403
Y699
S
G
L
S
I
D
E
Y
K
T
T
L
K
I
I
Rat
Rattus norvegicus
O54735
833
94538
Y667
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512580
863
98139
Y697
S
G
L
S
I
E
E
Y
K
T
T
L
K
M
I
Chicken
Gallus gallus
P52731
862
99990
F658
Q
N
L
N
K
R
Q
F
E
T
V
L
H
L
F
Frog
Xenopus laevis
NP_001088271
859
97399
Y689
S
G
L
S
V
Q
D
Y
K
T
V
L
K
M
I
Zebra Danio
Brachydanio rerio
XP_001923466
856
97075
Y695
S
G
L
S
L
D
E
Y
K
A
T
L
K
M
I
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
Y715
C
N
L
S
S
T
E
Y
S
D
L
M
Q
L
L
Fruit Fly
Dros. melanogaster
Q9VJ79
1451
160911
Y956
A
N
L
S
S
D
D
Y
C
R
V
I
R
V
L
Honey Bee
Apis mellifera
XP_394107
1016
115998
Y762
Q
S
L
S
M
E
D
Y
R
R
V
M
K
V
V
Nematode Worm
Caenorhab. elegans
P91119
710
81117
L583
S
E
D
Y
K
K
T
L
S
L
I
K
H
C
I
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
Y714
E
F
M
S
P
D
D
Y
R
E
A
I
R
M
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99
N.A.
N.A.
92.4
88.9
N.A.
87.8
25.1
75.1
71.1
38.1
31.2
37.5
26.6
39
Protein Similarity:
100
99.7
99.4
N.A.
N.A.
94.5
91
N.A.
91.6
44.2
85
83.1
58.1
41.3
54.6
44.2
55.9
P-Site Identity:
100
100
100
N.A.
N.A.
93.3
100
N.A.
93.3
20
66.6
73.3
26.6
20
33.3
13.3
13.3
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
100
53.3
93.3
93.3
53.3
66.6
73.3
20
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
0
0
8
8
0
0
0
0
% A
% Cys:
8
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% C
% Asp:
0
0
8
0
0
29
29
0
0
8
0
0
0
0
0
% D
% Glu:
8
8
0
0
0
43
58
0
8
8
0
0
0
0
0
% E
% Phe:
0
8
0
0
0
0
0
8
0
0
0
0
0
0
8
% F
% Gly:
0
58
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
15
0
0
% H
% Ile:
0
0
0
0
43
0
0
0
0
0
8
15
0
36
65
% I
% Lys:
0
0
0
0
15
8
0
0
58
0
0
8
65
0
0
% K
% Leu:
0
0
86
0
8
0
0
8
0
8
8
65
0
15
22
% L
% Met:
0
0
8
0
8
0
0
0
0
0
0
15
0
29
0
% M
% Asn:
0
22
0
8
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
15
0
0
0
0
8
8
0
0
0
0
0
8
0
0
% Q
% Arg:
0
0
0
0
0
8
0
0
15
15
0
0
15
0
0
% R
% Ser:
65
8
0
86
15
0
0
0
15
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
8
8
0
0
58
50
0
0
0
0
% T
% Val:
0
0
0
0
8
0
0
0
0
0
29
0
0
15
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
86
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _