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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SLC22A5
All Species:
30
Human Site:
Y84
Identified Species:
60
UniProt:
O76082
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76082
NP_003051.1
557
62752
Y84
V
P
H
S
C
R
R
Y
R
L
A
T
I
A
N
Chimpanzee
Pan troglodytes
XP_001163062
551
62237
Y84
V
P
H
S
C
S
R
Y
R
L
A
T
I
A
N
Rhesus Macaque
Macaca mulatta
XP_001103789
557
62650
Y84
V
P
H
S
C
R
R
Y
R
L
A
T
I
A
N
Dog
Lupus familis
XP_860734
557
62646
Y84
V
P
H
S
C
R
R
Y
R
L
A
A
I
A
N
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0E8
557
62761
Y84
V
P
Q
K
C
R
R
Y
R
L
A
T
I
A
N
Rat
Rattus norvegicus
O70594
557
62549
Y84
V
P
Q
S
C
R
R
Y
R
L
A
T
I
A
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510318
557
62019
Y84
G
P
S
R
C
R
R
Y
R
L
Q
A
L
R
N
Chicken
Gallus gallus
NP_001039293
557
62686
Y84
E
P
S
R
C
R
R
Y
R
L
A
V
L
A
N
Frog
Xenopus laevis
Q66KG0
566
63736
V81
T
S
K
D
Y
L
V
V
Q
Q
E
N
G
D
I
Zebra Danio
Brachydanio rerio
Q6NYN7
560
61953
R83
G
K
L
E
R
C
K
R
Y
T
T
P
Q
W
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VCA2
548
60985
Y83
C
S
Y
Y
D
V
D
Y
T
E
E
Y
L
N
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9U539
585
65444
Y97
Q
I
L
S
C
K
Q
Y
N
E
T
Q
I
N
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
76.1
98.1
90.3
N.A.
85.4
85.4
N.A.
72.1
75.7
31.9
31.9
N.A.
35.5
N.A.
29
N.A.
Protein Similarity:
100
86.7
99.6
95.8
N.A.
92.4
93
N.A.
84.5
86.5
54.9
50.1
N.A.
56
N.A.
49
N.A.
P-Site Identity:
100
93.3
100
93.3
N.A.
86.6
93.3
N.A.
53.3
66.6
0
0
N.A.
6.6
N.A.
26.6
N.A.
P-Site Similarity:
100
93.3
100
93.3
N.A.
86.6
93.3
N.A.
60
73.3
6.6
6.6
N.A.
20
N.A.
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
59
17
0
59
0
% A
% Cys:
9
0
0
0
75
9
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
9
9
0
9
0
0
0
0
0
0
9
0
% D
% Glu:
9
0
0
9
0
0
0
0
0
17
17
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
17
0
0
0
0
0
0
0
0
0
0
0
9
0
9
% G
% His:
0
0
34
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
9
0
0
0
0
0
0
0
0
0
0
59
0
9
% I
% Lys:
0
9
9
9
0
9
9
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
17
0
0
9
0
0
0
67
0
0
25
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
9
0
0
9
0
17
67
% N
% Pro:
0
67
0
0
0
0
0
0
0
0
0
9
0
0
0
% P
% Gln:
9
0
17
0
0
0
9
0
9
9
9
9
9
0
9
% Q
% Arg:
0
0
0
17
9
59
67
9
67
0
0
0
0
9
0
% R
% Ser:
0
17
17
50
0
9
0
0
0
0
0
0
0
0
0
% S
% Thr:
9
0
0
0
0
0
0
0
9
9
17
42
0
0
0
% T
% Val:
50
0
0
0
0
9
9
9
0
0
0
9
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% W
% Tyr:
0
0
9
9
9
0
0
84
9
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _