Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDE9A All Species: 13.64
Human Site: S569 Identified Species: 25
UniProt: O76083 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O76083 NP_001001567.1 593 68493 S569 E L Q K K T D S L T S G A T E
Chimpanzee Pan troglodytes XP_001140174 593 68430 S569 E L Q K K T D S L T S G A T E
Rhesus Macaque Macaca mulatta NP_001154921 533 61639 S509 E L Q K K T D S L T S G A T E
Dog Lupus familis XP_853727 850 94841 T623 G R R R L A Q T Q S G S A A S
Cat Felis silvestris
Mouse Mus musculus O70628 534 61617 S511 K K T E S L T S G A P E N T T
Rat Rattus norvegicus P14270 803 90534 S749 D T E K D S G S Q V E E D T S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511668 533 61943 D509 E L Q Q Q Q E D V T S G N T E
Chicken Gallus gallus XP_416748 516 59987 E492 E S R D R Y E E L K Q I D D A
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001340244 516 59766 Q493 D K Y E E L K Q I D D A M N E
Tiger Blowfish Takifugu rubipres Q1KKS3 903 102001 A876 D H G A S V P A S P C S A A E
Fruit Fly Dros. melanogaster P12252 1070 115060 R999 D E N P Q E D R I R F Q V T L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q22000 674 75370 E651 D Q L E E N R E W Y Q S R I P
Sea Urchin Strong. purpuratus XP_794310 409 47790 L386 Y R Y E E Q K L K E D Q I K E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 88.8 58.5 N.A. 83.1 24 N.A. 73.8 76.7 N.A. 67.6 21.1 20.1 N.A. 25.8 44.8
Protein Similarity: 100 99.4 89.3 61.4 N.A. 87.1 41.2 N.A. 80.2 82.4 N.A. 79.7 36.5 34.6 N.A. 44 56.8
P-Site Identity: 100 100 100 6.6 N.A. 13.3 20 N.A. 53.3 13.3 N.A. 6.6 13.3 13.3 N.A. 0 6.6
P-Site Similarity: 100 100 100 33.3 N.A. 26.6 40 N.A. 80 33.3 N.A. 33.3 26.6 33.3 N.A. 20 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 8 0 8 0 8 0 8 39 16 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % C
% Asp: 39 0 0 8 8 0 31 8 0 8 16 0 16 8 0 % D
% Glu: 39 8 8 31 24 8 16 16 0 8 8 16 0 0 54 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % F
% Gly: 8 0 8 0 0 0 8 0 8 0 8 31 0 0 0 % G
% His: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 16 0 0 8 8 8 0 % I
% Lys: 8 16 0 31 24 0 16 0 8 8 0 0 0 8 0 % K
% Leu: 0 31 8 0 8 16 0 8 31 0 0 0 0 0 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % M
% Asn: 0 0 8 0 0 8 0 0 0 0 0 0 16 8 0 % N
% Pro: 0 0 0 8 0 0 8 0 0 8 8 0 0 0 8 % P
% Gln: 0 8 31 8 16 16 8 8 16 0 16 16 0 0 0 % Q
% Arg: 0 16 16 8 8 0 8 8 0 8 0 0 8 0 0 % R
% Ser: 0 8 0 0 16 8 0 39 8 8 31 24 0 0 16 % S
% Thr: 0 8 8 0 0 24 8 8 0 31 0 0 0 54 8 % T
% Val: 0 0 0 0 0 8 0 0 8 8 0 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % W
% Tyr: 8 0 16 0 0 8 0 0 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _