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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE9A
All Species:
5.45
Human Site:
T235
Identified Species:
10
UniProt:
O76083
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76083
NP_001001567.1
593
68493
T235
L
D
N
H
K
K
L
T
P
R
R
D
V
P
T
Chimpanzee
Pan troglodytes
XP_001140174
593
68430
T235
L
D
N
H
K
K
L
T
P
R
R
D
V
P
T
Rhesus Macaque
Macaca mulatta
NP_001154921
533
61639
K198
E
T
V
E
A
L
R
K
P
T
F
D
V
W
L
Dog
Lupus familis
XP_853727
850
94841
D227
H
D
L
G
L
V
R
D
F
S
I
N
P
I
T
Cat
Felis silvestris
Mouse
Mus musculus
O70628
534
61617
F200
E
A
L
R
K
P
T
F
D
V
W
L
W
E
P
Rat
Rattus norvegicus
P14270
803
90534
F379
T
N
S
C
I
P
R
F
G
V
K
T
E
Q
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511668
533
61943
K198
E
T
I
E
A
L
R
K
P
T
F
D
V
W
L
Chicken
Gallus gallus
XP_416748
516
59987
P181
P
T
P
R
R
D
V
P
S
Y
P
K
Y
M
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001340244
516
59766
Y181
P
R
R
D
V
P
S
Y
P
K
Y
H
L
S
Q
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
C541
V
L
S
Y
H
A
T
C
S
K
T
E
V
D
K
Fruit Fly
Dros. melanogaster
P12252
1070
115060
M434
F
E
M
S
P
K
S
M
S
R
N
S
S
I
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q22000
674
75370
P330
P
S
H
D
G
H
V
P
E
Y
G
V
N
C
A
Sea Urchin
Strong. purpuratus
XP_794310
409
47790
P74
K
R
D
V
P
K
Y
P
K
Y
T
L
S
R
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
88.8
58.5
N.A.
83.1
24
N.A.
73.8
76.7
N.A.
67.6
21.1
20.1
N.A.
25.8
44.8
Protein Similarity:
100
99.4
89.3
61.4
N.A.
87.1
41.2
N.A.
80.2
82.4
N.A.
79.7
36.5
34.6
N.A.
44
56.8
P-Site Identity:
100
100
20
13.3
N.A.
6.6
0
N.A.
20
0
N.A.
6.6
6.6
13.3
N.A.
0
6.6
P-Site Similarity:
100
100
20
20
N.A.
6.6
20
N.A.
20
13.3
N.A.
20
40
20
N.A.
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
16
8
0
0
0
0
0
0
0
0
16
% A
% Cys:
0
0
0
8
0
0
0
8
0
0
0
0
0
8
0
% C
% Asp:
0
24
8
16
0
8
0
8
8
0
0
31
0
8
0
% D
% Glu:
24
8
0
16
0
0
0
0
8
0
0
8
8
8
16
% E
% Phe:
8
0
0
0
0
0
0
16
8
0
16
0
0
0
0
% F
% Gly:
0
0
0
8
8
0
0
0
8
0
8
0
0
0
0
% G
% His:
8
0
8
16
8
8
0
0
0
0
0
8
0
0
0
% H
% Ile:
0
0
8
0
8
0
0
0
0
0
8
0
0
16
0
% I
% Lys:
8
0
0
0
24
31
0
16
8
16
8
8
0
0
8
% K
% Leu:
16
8
16
0
8
16
16
0
0
0
0
16
8
0
24
% L
% Met:
0
0
8
0
0
0
0
8
0
0
0
0
0
8
0
% M
% Asn:
0
8
16
0
0
0
0
0
0
0
8
8
8
0
0
% N
% Pro:
24
0
8
0
16
24
0
24
39
0
8
0
8
16
8
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% Q
% Arg:
0
16
8
16
8
0
31
0
0
24
16
0
0
8
0
% R
% Ser:
0
8
16
8
0
0
16
0
24
8
0
8
16
8
0
% S
% Thr:
8
24
0
0
0
0
16
16
0
16
16
8
0
0
24
% T
% Val:
8
0
8
8
8
8
16
0
0
16
0
8
39
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
8
0
8
16
0
% W
% Tyr:
0
0
0
8
0
0
8
8
0
24
8
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _