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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE9A
All Species:
13.33
Human Site:
T74
Identified Species:
24.44
UniProt:
O76083
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76083
NP_001001567.1
593
68493
T74
M
P
A
N
S
E
R
T
P
Y
K
V
R
P
V
Chimpanzee
Pan troglodytes
XP_001140174
593
68430
T74
M
P
A
N
S
E
R
T
P
Y
K
V
R
P
V
Rhesus Macaque
Macaca mulatta
NP_001154921
533
61639
N70
I
D
P
T
M
P
A
N
S
E
R
T
P
Y
K
Dog
Lupus familis
XP_853727
850
94841
T74
M
P
A
N
S
K
S
T
P
Y
K
V
R
P
V
Cat
Felis silvestris
Mouse
Mus musculus
O70628
534
61617
E72
P
T
M
P
A
N
S
E
R
T
P
Y
K
V
R
Rat
Rattus norvegicus
P14270
803
90534
S209
S
R
N
S
S
I
A
S
D
I
H
G
D
D
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511668
533
61943
N70
I
D
P
T
M
P
A
N
S
E
R
T
P
Y
K
Chicken
Gallus gallus
XP_416748
516
59987
L53
P
R
N
T
T
I
S
L
L
T
A
D
N
C
M
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001340244
516
59766
D53
N
T
S
I
S
L
L
D
S
T
G
A
M
V
S
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
P106
V
N
S
R
A
Q
E
P
L
T
S
M
R
R
R
Fruit Fly
Dros. melanogaster
P12252
1070
115060
T83
M
S
S
S
A
G
T
T
G
Q
Q
S
K
Q
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q22000
674
75370
T158
H
G
D
D
L
I
V
T
P
F
A
Q
L
L
A
Sea Urchin
Strong. purpuratus
XP_794310
409
47790
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
88.8
58.5
N.A.
83.1
24
N.A.
73.8
76.7
N.A.
67.6
21.1
20.1
N.A.
25.8
44.8
Protein Similarity:
100
99.4
89.3
61.4
N.A.
87.1
41.2
N.A.
80.2
82.4
N.A.
79.7
36.5
34.6
N.A.
44
56.8
P-Site Identity:
100
100
0
86.6
N.A.
0
6.6
N.A.
0
0
N.A.
6.6
6.6
13.3
N.A.
13.3
0
P-Site Similarity:
100
100
13.3
93.3
N.A.
13.3
26.6
N.A.
13.3
13.3
N.A.
13.3
40
46.6
N.A.
26.6
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
24
0
24
0
24
0
0
0
16
8
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
16
8
8
0
0
0
8
8
0
0
8
8
8
8
% D
% Glu:
0
0
0
0
0
16
8
8
0
16
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
8
0
0
8
0
8
8
0
0
0
% G
% His:
8
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% H
% Ile:
16
0
0
8
0
24
0
0
0
8
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
8
0
0
0
0
24
0
16
0
16
% K
% Leu:
0
0
0
0
8
8
8
8
16
0
0
0
8
8
8
% L
% Met:
31
0
8
0
16
0
0
0
0
0
0
8
8
0
8
% M
% Asn:
8
8
16
24
0
8
0
16
0
0
0
0
8
0
0
% N
% Pro:
16
24
16
8
0
16
0
8
31
0
8
0
16
24
0
% P
% Gln:
0
0
0
0
0
8
0
0
0
8
8
8
0
8
0
% Q
% Arg:
0
16
0
8
0
0
16
0
8
0
16
0
31
8
16
% R
% Ser:
8
8
24
16
39
0
24
8
24
0
8
8
0
0
8
% S
% Thr:
0
16
0
24
8
0
8
39
0
31
0
16
0
0
0
% T
% Val:
8
0
0
0
0
0
8
0
0
0
0
24
0
16
24
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
24
0
8
0
16
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _