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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE9A
All Species:
8.79
Human Site:
Y359
Identified Species:
16.11
UniProt:
O76083
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76083
NP_001001567.1
593
68493
Y359
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
Chimpanzee
Pan troglodytes
XP_001140174
593
68430
Y359
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
Rhesus Macaque
Macaca mulatta
NP_001154921
533
61639
I318
L
A
V
R
Y
N
D
I
S
P
L
E
N
H
H
Dog
Lupus familis
XP_853727
850
94841
F349
A
N
V
Q
P
D
G
F
K
Q
I
K
Q
G
M
Cat
Felis silvestris
Mouse
Mus musculus
O70628
534
61617
L320
R
Y
N
D
I
S
P
L
E
N
H
H
C
A
I
Rat
Rattus norvegicus
P14270
803
90534
V504
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511668
533
61943
I318
L
A
V
R
Y
N
D
I
S
P
L
E
N
H
H
Chicken
Gallus gallus
XP_416748
516
59987
N301
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001340244
516
59766
Y301
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
T665
H
D
L
D
H
R
G
T
N
N
A
F
Q
A
K
Fruit Fly
Dros. melanogaster
P12252
1070
115060
L779
H
D
V
D
H
P
G
L
T
N
Q
F
L
V
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q22000
674
75370
F454
H
D
V
D
H
P
G
F
T
N
Q
Y
L
I
N
Sea Urchin
Strong. purpuratus
XP_794310
409
47790
Q194
P
G
F
N
N
T
Y
Q
I
N
A
R
T
D
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
88.8
58.5
N.A.
83.1
24
N.A.
73.8
76.7
N.A.
67.6
21.1
20.1
N.A.
25.8
44.8
Protein Similarity:
100
99.4
89.3
61.4
N.A.
87.1
41.2
N.A.
80.2
82.4
N.A.
79.7
36.5
34.6
N.A.
44
56.8
P-Site Identity:
100
100
0
13.3
N.A.
13.3
60
N.A.
0
6.6
N.A.
13.3
60
53.3
N.A.
66.6
6.6
P-Site Similarity:
100
100
26.6
33.3
N.A.
20
80
N.A.
26.6
6.6
N.A.
26.6
66.6
73.3
N.A.
80
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
16
0
0
0
0
0
0
0
0
16
8
0
24
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% C
% Asp:
0
54
0
54
0
8
16
0
0
0
0
0
0
8
0
% D
% Glu:
0
0
0
0
0
0
0
0
8
0
0
16
0
0
8
% E
% Phe:
0
0
8
0
0
0
0
16
0
0
0
24
0
0
0
% F
% Gly:
0
8
8
0
8
0
54
0
0
0
0
0
0
8
0
% G
% His:
54
0
8
0
47
0
0
0
0
0
8
8
0
16
16
% H
% Ile:
0
0
0
0
8
0
0
16
8
8
8
8
0
31
8
% I
% Lys:
0
0
0
0
0
0
0
0
8
0
0
8
0
0
8
% K
% Leu:
24
0
24
0
0
0
0
16
0
0
16
0
24
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
8
8
8
16
24
8
8
24
62
8
0
24
0
39
% N
% Pro:
8
8
0
8
8
39
8
0
0
16
0
0
0
0
0
% P
% Gln:
0
0
0
8
0
0
0
8
8
8
31
0
31
0
0
% Q
% Arg:
8
0
0
16
0
8
0
0
0
0
0
8
8
0
8
% R
% Ser:
0
0
0
0
0
8
0
0
24
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
8
8
8
24
0
16
0
8
8
0
% T
% Val:
0
0
47
0
0
0
0
8
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
8
16
8
8
24
0
8
0
24
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _